Crich D - Search Results

1

Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia.

Hill J, Givhan RH, Yi B, Jones RM, Douglass EF, Xi Y, Schaefer HF 3rd, Crich D. Hill J, et al. Among authors: crich d. J Med Chem. 2024 Oct 10;67(19):17820-17832. doi: 10.1021/acs.jmedchem.4c01852. Epub 2024 Sep 23. J Med Chem. 2024. PMID: 39311765 Free PMC article.

2

Diversity-Oriented Synthesis of N,N,O-Trisubstituted Hydroxylamines from Alcohols and Amines by N-O Bond Formation.

Hill J, Hettikankanamalage AA, Crich D. Hill J, et al. Among authors: crich d. J Am Chem Soc. 2020 Sep 2;142(35):14820-14825. doi: 10.1021/jacs.0c05991. Epub 2020 Aug 24. J Am Chem Soc. 2020. PMID: 32803971

3

Synthesis of O-tert-Butyl-N,N-disubstituted Hydroxylamines by N-O Bond Formation.

Hill J, Crich D. Hill J, et al. Among authors: crich d. Org Lett. 2021 Aug 20;23(16):6396-6400. doi: 10.1021/acs.orglett.1c02215. Epub 2021 Jul 30. Org Lett. 2021. PMID: 34328741

4

Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.

Freitas BT, Ahiadorme DA, Bagul RS, Durie IA, Ghosh S, Hill J, Kramer NE, Murray J, O'Boyle BM, Onobun E, Pirrone MG, Shepard JD, Enos S, Subedi YP, Upadhyaya K, Tripp RA, Cummings BS, Crich D, Pegan SD. Freitas BT, et al. Among authors: crich d. ACS Infect Dis. 2022 Mar 11;8(3):596-611. doi: 10.1021/acsinfecdis.1c00631. Epub 2022 Feb 24. ACS Infect Dis. 2022. PMID: 35199517 Free PMC article.

5

The N,N,O-Trisubstituted Hydroxylamine Isostere and Its Influence on Lipophilicity and Related Parameters.

Hill J, Crich D. Hill J, et al. Among authors: crich d. ACS Med Chem Lett. 2022 Apr 20;13(5):799-806. doi: 10.1021/acsmedchemlett.1c00713. eCollection 2022 May 12. ACS Med Chem Lett. 2022. PMID: 35586423 Free PMC article.

6

Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines.

Hill J, Beckler TD, Crich D. Hill J, et al. Among authors: crich d. Molecules. 2023 Mar 21;28(6):2816. doi: 10.3390/molecules28062816. Molecules. 2023. PMID: 36985788 Free PMC article. Review.

7

Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer.

Hill J, Jones RM, Crich D. Hill J, et al. Among authors: crich d. J Med Chem. 2023 Nov 23;66(22):15477-15492. doi: 10.1021/acs.jmedchem.3c01669. Epub 2023 Nov 7. J Med Chem. 2023. PMID: 37934858 Free PMC article.

8

Atypical N-Alkyl to N-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity.

Hill J, Jones RM, Crich D. Hill J, et al. Among authors: crich d. ACS Med Chem Lett. 2023 Dec 5;14(12):1869-1875. doi: 10.1021/acsmedchemlett.3c00479. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116407 Free PMC article.

9

Influence of Configuration at the 4- and 6-Positions on the Conformation and Anomeric Reactivity and Selectivity of 7-Deoxyheptopyranosyl Donors: Discovery of a Highly Equatorially Selective l-glycero-d-gluco-Heptopyranosyl Donor.

Upadhyaya K, Bagul RS, Crich D. Upadhyaya K, et al. Among authors: crich d. J Org Chem. 2021 Sep 3;86(17):12199-12225. doi: 10.1021/acs.joc.1c01535. Epub 2021 Aug 3. J Org Chem. 2021. PMID: 34343001 Free PMC article.

10

Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity.

Pirrone MG, Hobbie SN, Vasella A, Böttger EC, Crich D. Pirrone MG, et al. Among authors: crich d. RSC Med Chem. 2021 Aug 5;12(9):1585-1591. doi: 10.1039/d1md00214g. eCollection 2021 Sep 23. RSC Med Chem. 2021. PMID: 34671740 Free PMC article.

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