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Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.
Blazanin N, Liang X, Mahmud I, Kim E, Martinez S, Tan L, Chan W, Anvar NE, Ha MJ, Qudratullah M, Minelli R, Peoples M, Lorenzi P, Hart T, Lissanu Y. Blazanin N, et al. Among authors: chan w. bioRxiv [Preprint]. 2024 Sep 20:2024.09.16.613317. doi: 10.1101/2024.09.16.613317. bioRxiv. 2024. PMID: 39345502 Free PMC article. Preprint.
Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer.
Bowen MB, Melendez B, Zhang Q, Moreno D, Peralta L, Chan WK, Jeter C, Tan L, Zal MA, Lorenzi PL, Dunner K, Yang RK, Broaddus RR, Celestino J, Gokul N, Whitley E, Schmandt R, Lu K, Kim HE, Yates MS. Bowen MB, et al. bioRxiv [Preprint]. 2024 Jun 11:2024.06.10.596841. doi: 10.1101/2024.06.10.596841. bioRxiv. 2024. PMID: 38915709 Free PMC article. Preprint.
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer.
Cargill KR, Stewart CA, Park EM, Ramkumar K, Gay CM, Cardnell RJ, Wang Q, Diao L, Shen L, Fan YH, Chan WK, Lorenzi PL, Oliver TG, Wang J, Byers LA. Cargill KR, et al. Cancer Metab. 2021 Sep 23;9(1):33. doi: 10.1186/s40170-021-00270-9. Cancer Metab. 2021. PMID: 34556188 Free PMC article.
Mechanism of Catalysis by l-Asparaginase.
Lubkowski J, Vanegas J, Chan WK, Lorenzi PL, Weinstein JN, Sukharev S, Fushman D, Rempe S, Anishkin A, Wlodawer A. Lubkowski J, et al. Biochemistry. 2020 May 26;59(20):1927-1945. doi: 10.1021/acs.biochem.0c00116. Epub 2020 May 11. Biochemistry. 2020. PMID: 32364696
7,180 results