Chan WK - Search Results

1

Ultra-Fast Multi-Organ Proteomics Unveils Tissue-Specific Mechanisms of Drug Efficacy and Toxicity.

Xiong Y, Tan L, Chan WK, Yin ES, Donepudi SR, Ding J, Wei B, Tran B, Martinez S, Mahmud I, Stewart HI, Hermanson DJ, Weinstein JN, Lorenzi PL. Xiong Y, et al. Among authors: chan wk. bioRxiv [Preprint]. 2024 Oct 5:2024.09.25.615060. doi: 10.1101/2024.09.25.615060. bioRxiv. 2024. PMID: 39386681 Free PMC article. Preprint.

2

Therapeutic modulation of ROCK overcomes metabolic adaptation of cancer cells to OXPHOS inhibition and drives synergistic anti-tumor activity.

Blazanin N, Liang X, Mahmud I, Kim E, Martinez S, Tan L, Chan W, Anvar NE, Ha MJ, Qudratullah M, Minelli R, Peoples M, Lorenzi P, Hart T, Lissanu Y. Blazanin N, et al. bioRxiv [Preprint]. 2024 Sep 20:2024.09.16.613317. doi: 10.1101/2024.09.16.613317. bioRxiv. 2024. PMID: 39345502 Free PMC article. Preprint.

3

Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer.

Bowen MB, Melendez B, Zhang Q, Moreno D, Peralta L, Chan WK, Jeter C, Tan L, Zal MA, Lorenzi PL, Dunner K, Yang RK, Broaddus RR, Celestino J, Gokul N, Whitley E, Schmandt R, Lu K, Kim HE, Yates MS. Bowen MB, et al. Among authors: chan wk. bioRxiv [Preprint]. 2024 Jun 11:2024.06.10.596841. doi: 10.1101/2024.06.10.596841. bioRxiv. 2024. PMID: 38915709 Free PMC article. Preprint.

4

Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer.

Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M, Weinstein JN, Lorenzi PL. Horvath TD, et al. Among authors: chan wk. Metabolites. 2019 Jan 9;9(1):10. doi: 10.3390/metabo9010010. Metabolites. 2019. PMID: 30634463 Free PMC article.

5

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.

Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL. Chan WK, et al. Mol Cancer Ther. 2019 Sep;18(9):1587-1592. doi: 10.1158/1535-7163.MCT-18-1329. Epub 2019 Jun 17. Mol Cancer Ther. 2019. PMID: 31209181 Free PMC article.

6

Response envelope analysis for quantitative evaluation of drug combinations.

Du D, Chang CH, Wang Y, Tong P, Chan WK, Chiu Y, Peng B, Tan L, Weinstein JN, Lorenzi PL. Du D, et al. Among authors: chan wk. Bioinformatics. 2019 Oct 1;35(19):3761-3770. doi: 10.1093/bioinformatics/btz091. Bioinformatics. 2019. PMID: 30851108 Free PMC article.

7

Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.

Anishkin A, Vanegas JM, Rogers DM, Lorenzi PL, Chan WK, Purwaha P, Weinstein JN, Sukharev S, Rempe SB. Anishkin A, et al. Among authors: chan wk. J Mol Biol. 2015 Aug 28;427(17):2867-85. doi: 10.1016/j.jmb.2015.06.017. Epub 2015 Jul 2. J Mol Biol. 2015. PMID: 26142822

8

The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.

Chan WK, Lorenzi PL, Anishkin A, Purwaha P, Rogers DM, Sukharev S, Rempe SB, Weinstein JN. Chan WK, et al. Blood. 2014 Jun 5;123(23):3596-606. doi: 10.1182/blood-2013-10-535112. Epub 2014 Mar 21. Blood. 2014. PMID: 24659632 Free PMC article.

9

Mechanism of Catalysis by l-Asparaginase.

Lubkowski J, Vanegas J, Chan WK, Lorenzi PL, Weinstein JN, Sukharev S, Fushman D, Rempe S, Anishkin A, Wlodawer A. Lubkowski J, et al. Among authors: chan wk. Biochemistry. 2020 May 26;59(20):1927-1945. doi: 10.1021/acs.biochem.0c00116. Epub 2020 May 11. Biochemistry. 2020. PMID: 32364696

10

Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.

Grima-Reyes M, Vandenberghe A, Nemazanyy I, Meola P, Paul R, Reverso-Meinietti J, Martinez-Turtos A, Nottet N, Chan WK, Lorenzi PL, Marchetti S, Ricci JE, Chiche J. Grima-Reyes M, et al. Among authors: chan wk. Sci Adv. 2022 Jul 8;8(27):eabn6491. doi: 10.1126/sciadv.abn6491. Epub 2022 Jul 6. Sci Adv. 2022. PMID: 35857457 Free PMC article.

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