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124 results

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Page 1
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo.
Dernovšek J, Urbančič D, Zajec Ž, Sturtzel C, Grissenberger S, Wenninger-Weinzierl A, Gedgaudas M, Zubrienė A, Goričan T, Golič Grdadolnik S, Skok Ž, Ilaš J, Distel M, Zidar N, Tomašič T. Dernovšek J, et al. Among authors: distel m. Bioorg Chem. 2024 Oct 1;153:107850. doi: 10.1016/j.bioorg.2024.107850. Online ahead of print. Bioorg Chem. 2024. PMID: 39395321 Free article.
Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency.
Dernovšek J, Zajec Ž, Poje G, Urbančič D, Sturtzel C, Goričan T, Grissenberger S, Ciura K, Woziński M, Gedgaudas M, Zubrienė A, Grdadolnik SG, Mlinarič-Raščan I, Rajić Z, Cotman AE, Zidar N, Distel M, Tomašič T. Dernovšek J, et al. Among authors: distel m. Biomed Pharmacother. 2024 Aug;177:116941. doi: 10.1016/j.biopha.2024.116941. Epub 2024 Jun 17. Biomed Pharmacother. 2024. PMID: 38889640 Free article.
Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders.
Dernovšek J, Goričan T, Gedgaudas M, Zajec Ž, Urbančič D, Jug A, Skok Ž, Sturtzel C, Distel M, Grdadolnik SG, Babu K, Panchamatia A, Stachowski TR, Fischer M, Ilaš J, Zubrienė A, Matulis D, Zidar N, Tomašič T. Dernovšek J, et al. Among authors: distel m. Eur J Med Chem. 2024 Oct 5;280:116934. doi: 10.1016/j.ejmech.2024.116934. Online ahead of print. Eur J Med Chem. 2024. PMID: 39388906 Free article.
YB-1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2.
Schelch K, Eder S, Zitta B, Phimmachanh M, Johnson TG, Emminger D, Wenninger-Weinzierl A, Sturtzel C, Poplimont H, Ries A, Hoetzenecker K, Hoda MA, Berger W, Distel M, Dome B, Reid G, Grusch M. Schelch K, et al. Among authors: distel m. Mol Oncol. 2024 Apr;18(4):815-831. doi: 10.1002/1878-0261.13367. Epub 2023 Jan 25. Mol Oncol. 2024. PMID: 36550787 Free PMC article.
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.
Saldana-Guerrero IM, Montano-Gutierrez LF, Boswell K, Hafemeister C, Poon E, Shaw LE, Stavish D, Lea RA, Wernig-Zorc S, Bozsaky E, Fetahu IS, Zoescher P, Pötschger U, Bernkopf M, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S, Shoeb MR, Bozatzi P, Rados M, Guarini M, Buri MC, Weninger W, Putz EM, Huang M, Ladenstein R, Andrews PW, Barbaric I, Cresswell GD, Bryant HE, Distel M, Chesler L, Taschner-Mandl S, Farlik M, Tsakiridis A, Halbritter F. Saldana-Guerrero IM, et al. Among authors: distel m. Nat Commun. 2024 May 3;15(1):3745. doi: 10.1038/s41467-024-47945-7. Nat Commun. 2024. PMID: 38702304 Free PMC article.
Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation.
Kirchberger S, Shoeb MR, Lazic D, Wenninger-Weinzierl A, Fischer K, Shaw LE, Nogueira F, Rifatbegovic F, Bozsaky E, Ladenstein R, Bodenmiller B, Lion T, Traver D, Farlik M, Schöfer C, Taschner-Mandl S, Halbritter F, Distel M. Kirchberger S, et al. Among authors: distel m. Nat Commun. 2024 Feb 27;15(1):1792. doi: 10.1038/s41467-024-45802-1. Nat Commun. 2024. PMID: 38413586 Free PMC article.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug K. Block J, et al. Among authors: distel m. N Engl J Med. 2023 Aug 10;389(6):527-539. doi: 10.1056/NEJMoa2210054. Epub 2023 Jun 21. N Engl J Med. 2023. PMID: 37342957
Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts.
Sturtzel C, Grissenberger S, Bozatzi P, Scheuringer E, Wenninger-Weinzierl A, Zajec Z, Dernovšek J, Pascoal S, Gehl V, Kutsch A, Granig A, Rifatbegovic F, Carre M, Lang A, Valtingojer I, Moll J, Lötsch D, Erhart F, Widhalm G, Surdez D, Delattre O, André N, Stampfl J, Tomašič T, Taschner-Mandl S, Distel M. Sturtzel C, et al. Among authors: distel m. NPJ Precis Oncol. 2023 May 18;7(1):44. doi: 10.1038/s41698-023-00386-9. NPJ Precis Oncol. 2023. PMID: 37202469 Free PMC article. Review.
124 results