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Page 1
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: gee ct. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BA. Scott DC, et al. Among authors: gee ct. Mol Cell. 2023 Mar 2;83(5):770-786.e9. doi: 10.1016/j.molcel.2023.01.019. Epub 2023 Feb 16. Mol Cell. 2023. PMID: 36805027 Free PMC article.
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: gee ct. J Med Chem. 2022 Feb 10;65(3):2342-2360. doi: 10.1021/acs.jmedchem.1c01779. Epub 2022 Jan 10. J Med Chem. 2022. PMID: 35007061 Free PMC article.
27 results