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Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.
Vidal-Calvo EE, Martin-Salazar A, Choudhary S, Dagil R, Raghavan SSR, Duvnjak L, Nordmaj MA, Clausen TM, Skafte A, Oberkofler J, Wang K, Agerbæk MØ, Løppke C, Jørgensen AM, Ropac D, Mujollari J, Willis S, Garcias López A, Miller RL, Karlsson RTG, Goerdeler F, Chen YH, Colaço AR, Wang Y, Lavstsen T, Martowicz A, Nelepcu I, Marzban M, Oo HZ, Ørum-Madsen MS, Wang Y, Nielsen MA, Clausen H, Wierer M, Wolf D, Gögenur I, Theander TG, Al-Nakouzi N, Gustavsson T, Daugaard M, Salanti A. Vidal-Calvo EE, et al. Among authors: lavstsen t. Nat Commun. 2024 Aug 30;15(1):7553. doi: 10.1038/s41467-024-51781-0. Nat Commun. 2024. PMID: 39215044 Free PMC article.
Antibodies to PfEMP1 and variant surface antigens: Protection after controlled human malaria infection in semi-immune Kenyan adults.
Kinyua AW, Turner L, Kimingi HW, Mwai K, Mwikali K, Andisi C, Sim BKL, Bejon P, Kapulu MC, Kinyanjui SM, Lavstsen T, Abdi AI; CHMI-SIKA Study Team. Kinyua AW, et al. Among authors: lavstsen t. J Infect. 2024 Oct;89(4):106252. doi: 10.1016/j.jinf.2024.106252. Epub 2024 Aug 23. J Infect. 2024. PMID: 39182654 Free PMC article.
Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.
Reyes RA, Turner L, Ssewanyana I, Jagannathan P, Feeney ME, Lavstsen T, Greenhouse B, Bol S, Bunnik EM. Reyes RA, et al. Among authors: lavstsen t. bioRxiv [Preprint]. 2024 Jun 3:2024.06.01.596978. doi: 10.1101/2024.06.01.596978. bioRxiv. 2024. Update in: PLoS Pathog. 2024 Oct 28;20(10):e1012661. doi: 10.1371/journal.ppat.1012661. PMID: 38895251 Free PMC article. Updated. Preprint.
Broadly inhibitory antibodies against severe malaria virulence proteins.
Reyes RA, Raghavan SSR, Hurlburt NK, Introini V, Kana IH, Jensen RW, Martinez-Scholze E, Gestal-Mato M, Bau CB, Fernández-Quintero ML, Loeffler JR, Ferguson JA, Lee WH, Martin GM, Theander TG, Ssewanyana I, Feeney ME, Greenhouse B, Bol S, Ward AB, Bernabeu M, Pancera M, Turner L, Bunnik EM, Lavstsen T. Reyes RA, et al. Among authors: lavstsen t. bioRxiv [Preprint]. 2024 Jan 25:2024.01.25.577124. doi: 10.1101/2024.01.25.577124. bioRxiv. 2024. PMID: 38328068 Free PMC article. Preprint.
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture.
Andradi-Brown C, Wichers-Misterek JS, von Thien H, Höppner YD, Scholz JAM, Hansson H, Filtenborg Hocke E, Gilberger TW, Duffy MF, Lavstsen T, Baum J, Otto TD, Cunnington AJ, Bachmann A. Andradi-Brown C, et al. Among authors: lavstsen t. Elife. 2024 Jan 25;12:RP87726. doi: 10.7554/eLife.87726. Elife. 2024. PMID: 38270586 Free PMC article.
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA.
Raghavan SSR, Dagil R, Lopez-Perez M, Conrad J, Bassi MR, Quintana MDP, Choudhary S, Gustavsson T, Wang Y, Gourdon P, Ofori MF, Christensen SB, Minja DTR, Schmiegelow C, Nielsen MA, Barfod L, Hviid L, Salanti A, Lavstsen T, Wang K. Raghavan SSR, et al. Among authors: lavstsen t. PLoS Pathog. 2022 Nov 16;18(11):e1010924. doi: 10.1371/journal.ppat.1010924. eCollection 2022 Nov. PLoS Pathog. 2022. PMID: 36383559 Free PMC article.
88 results