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Age-associated contraction of tumor-specific T cells impairs antitumor immunity.
Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE. Georgiev P, et al. Among authors: haigis mc. Cancer Immunol Res. 2024 Aug 24. doi: 10.1158/2326-6066.CIR-24-0463. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39186561
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
Pannek M, Alhalabi Z, Tomaselli D, Menna M, Fiorentino F, Robaa D, Weyand M, Puhlmann M, Tomassi S, Barreca F, Tafani M, Zaganjor E, Haigis MC, Sippl W, Rotili D, Mai A, Steegborn C. Pannek M, et al. Among authors: haigis mc. J Med Chem. 2024 Feb 8;67(3):1843-1860. doi: 10.1021/acs.jmedchem.3c01496. Epub 2024 Jan 22. J Med Chem. 2024. PMID: 38253001
Regulatory T cells in dominant immunologic tolerance.
Georgiev P, Benamar M, Han S, Haigis MC, Sharpe AH, Chatila TA. Georgiev P, et al. Among authors: haigis mc. J Allergy Clin Immunol. 2024 Jan;153(1):28-41. doi: 10.1016/j.jaci.2023.09.025. Epub 2023 Sep 29. J Allergy Clin Immunol. 2024. PMID: 37778472 Review.
Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.
Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AH. Rowe JH, et al. Among authors: haigis mc. Cancer Discov. 2023 Dec 12;13(12):2566-2583. doi: 10.1158/2159-8290.CD-22-1301. Cancer Discov. 2023. PMID: 37728660 Free PMC article.
Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC. Kurmi K, et al. Among authors: haigis mc. Cell Chem Biol. 2023 Sep 21;30(9):1064-1075.e8. doi: 10.1016/j.chembiol.2023.08.008. Cell Chem Biol. 2023. PMID: 37716347 Free PMC article.
116 results