Lentini L - Search Results

1

Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression.

Fiduccia I, Corrao F, Zizzo MG, Perriera R, Genovese F, Vitale E, Ricci D, Melfi R, Tutone M, Pace A, Lentini L, Pibiri I. Fiduccia I, et al. Among authors: lentini l. Mol Ther. 2024 Oct 28:S1525-0016(24)00688-9. doi: 10.1016/j.ymthe.2024.10.028. Online ahead of print. Mol Ther. 2024. PMID: 39473179 Free article.

2

Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2'-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR.

Carollo PS, Tutone M, Culletta G, Fiduccia I, Corrao F, Pibiri I, Di Leonardo A, Zizzo MG, Melfi R, Pace A, Almerico AM, Lentini L. Carollo PS, et al. Among authors: lentini l. Int J Mol Sci. 2023 Jun 1;24(11):9609. doi: 10.3390/ijms24119609. Int J Mol Sci. 2023. PMID: 37298560 Free PMC article.

3

Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening.

Pibiri I, Lentini L, Tutone M, Melfi R, Pace A, Di Leonardo A. Pibiri I, et al. Among authors: lentini l. Eur J Med Chem. 2016 Oct 21;122:429-435. doi: 10.1016/j.ejmech.2016.06.048. Epub 2016 Jun 29. Eur J Med Chem. 2016. PMID: 27404557

4

Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs.

Pibiri I, Lentini L, Melfi R, Tutone M, Baldassano S, Ricco Galluzzo P, Di Leonardo A, Pace A. Pibiri I, et al. Among authors: lentini l. Eur J Med Chem. 2018 Nov 5;159:126-142. doi: 10.1016/j.ejmech.2018.09.057. Epub 2018 Sep 26. Eur J Med Chem. 2018. PMID: 30278331

5

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs).

Campofelice A, Lentini L, Di Leonardo A, Melfi R, Tutone M, Pace A, Pibiri I. Campofelice A, et al. Among authors: lentini l. Int J Mol Sci. 2019 Jul 6;20(13):3329. doi: 10.3390/ijms20133329. Int J Mol Sci. 2019. PMID: 31284579 Free PMC article. Review.

6

Targeting Nonsense: Optimization of 1,2,4-Oxadiazole TRIDs to Rescue CFTR Expression and Functionality in Cystic Fibrosis Cell Model Systems.

Pibiri I, Melfi R, Tutone M, Di Leonardo A, Pace A, Lentini L. Pibiri I, et al. Among authors: lentini l. Int J Mol Sci. 2020 Sep 3;21(17):6420. doi: 10.3390/ijms21176420. Int J Mol Sci. 2020. PMID: 32899265 Free PMC article.

7

Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation.

Corrao F, Zizzo MG, Tutone M, Melfi R, Fiduccia I, Carollo PS, Leonardo AD, Caldara G, Perriera R, Pace A, Belmonte B, Sammataro S, Pibiri I, Lentini L. Corrao F, et al. Among authors: lentini l. Biomed Pharmacother. 2022 Dec;156:113886. doi: 10.1016/j.biopha.2022.113886. Epub 2022 Oct 18. Biomed Pharmacother. 2022. PMID: 36265311 Free article.

8

Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression.

Perriera R, Vitale E, Pibiri I, Carollo PS, Ricci D, Corrao F, Fiduccia I, Melfi R, Zizzo MG, Tutone M, Pace A, Lentini L. Perriera R, et al. Among authors: lentini l. Int J Mol Sci. 2023 Oct 11;24(20):15084. doi: 10.3390/ijms242015084. Int J Mol Sci. 2023. PMID: 37894764 Free PMC article.

9

Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives.

Pibiri I, Lentini L, Melfi R, Gallucci G, Pace A, Spinello A, Barone G, Di Leonardo A. Pibiri I, et al. Among authors: lentini l. Eur J Med Chem. 2015 Aug 28;101:236-44. doi: 10.1016/j.ejmech.2015.06.038. Epub 2015 Jun 21. Eur J Med Chem. 2015. PMID: 26142488

10

Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study.

Tutone M, Pibiri I, Lentini L, Pace A, Almerico AM. Tutone M, et al. Among authors: lentini l. ACS Med Chem Lett. 2019 Feb 7;10(4):522-527. doi: 10.1021/acsmedchemlett.8b00558. eCollection 2019 Apr 11. ACS Med Chem Lett. 2019. PMID: 30996790 Free PMC article.

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