Chen J - Search Results

1

Palladium-Mediated Bioorthogonal System for Prodrug Activation of N-Benzylbenzamide-Containing Tubulin Polymerization Inhibitors for the Treatment of Solid Tumors.

Li J, Zhang T, Wu D, He C, Weng H, Zheng T, Liu J, Yao H, Chen J, Ren Y, Zhu Z, Xu J, Xu S. Li J, et al. Among authors: chen j. J Med Chem. 2024 Nov 14;67(21):19905-19924. doi: 10.1021/acs.jmedchem.4c02419. Epub 2024 Nov 1. J Med Chem. 2024. PMID: 39484713

2

Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo.

Zhu H, Zhu W, Liu Y, Gao T, Zhu J, Tan Y, Hu H, Liang W, Zhao L, Chen J, Zhu Z, Chen J, Xu J, Xu S. Zhu H, et al. Among authors: chen j. Eur J Med Chem. 2023 Sep 5;257:115529. doi: 10.1016/j.ejmech.2023.115529. Epub 2023 May 30. Eur J Med Chem. 2023. PMID: 37269670

3

Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents.

Chen J, Wang T, Xu S, Lin A, Yao H, Xie W, Zhu Z, Xu J. Chen J, et al. Eur J Med Chem. 2017 May 26;132:173-183. doi: 10.1016/j.ejmech.2017.03.027. Epub 2017 Mar 18. Eur J Med Chem. 2017. PMID: 28359045

4

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H₂O₂-Induced Apoptosis.

Chen J, Wang R, Wang T, Ding Q, Khalil A, Xu S, Lin A, Yao H, Xie W, Zhu Z, Xu J. Chen J, et al. ACS Med Chem Lett. 2017 Mar 13;8(4):443-448. doi: 10.1021/acsmedchemlett.7b00035. eCollection 2017 Apr 13. ACS Med Chem Lett. 2017. PMID: 28435534 Free PMC article.

5

Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway.

Chen J, Wang T, Xu S, Zhang P, Lin A, Wu L, Yao H, Xie W, Zhu Z, Xu J. Chen J, et al. Eur J Med Chem. 2017 Jul 28;135:414-423. doi: 10.1016/j.ejmech.2017.04.045. Epub 2017 Apr 20. Eur J Med Chem. 2017. PMID: 28463784 Free article.

6

Development of novel 9-O-substituted-13-octylberberine derivatives as potential anti-hepatocellular carcinoma agents.

Chen J, Duan Y, Yu X, Zhong J, Bai J, Li NG, Zhu Z, Xu J. Chen J, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2423-2433. doi: 10.1080/14756366.2022.2118268. J Enzyme Inhib Med Chem. 2022. PMID: 36065941 Free PMC article.

7

Design, synthesis and biological evaluation of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine as anti-hepatocellular carcinoma agents.

Chen J, Duan Y, Yang K, Wang J, Yan J, Gu C, Wang S, Zhu Z, Liu EH, Xu J. Chen J, et al. Bioorg Med Chem. 2023 Feb 1;79:117156. doi: 10.1016/j.bmc.2023.117156. Epub 2023 Jan 8. Bioorg Med Chem. 2023. PMID: 36640595

8

Design, synthesis, and biological evaluation of novel HPK1 inhibitors possessing 3-cyano-quinoline moiety.

Chen L, Zhang B, Zhou P, Duan Y, He C, Zhong W, Wang T, Xu S, Chen J, Yao H, Xu J. Chen L, et al. Among authors: chen j. Bioorg Chem. 2024 Sep 12;153:107814. doi: 10.1016/j.bioorg.2024.107814. Online ahead of print. Bioorg Chem. 2024. PMID: 39299176

9

Novel hybrids of natural β-elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility.

Chen J, Wang T, Xu S, Lin A, Yao H, Xie W, Zhu Z, Xu J. Chen J, et al. Fitoterapia. 2017 Jul;120:117-125. doi: 10.1016/j.fitote.2017.05.002. Epub 2017 May 31. Fitoterapia. 2017. PMID: 28576721

10

Cobalt-catalyzed carbon-sulfur/selenium bond formation: synthesis of benzo[b]thio/selenophene-fused imidazo[1,2-a]pyridines.

Wang T, Chen J, Wang J, Xu S, Lin A, Yao H, Jiang S, Xu J. Wang T, et al. Among authors: chen j. Org Biomol Chem. 2018 May 23;16(20):3721-3725. doi: 10.1039/c8ob00743h. Org Biomol Chem. 2018. PMID: 29737996

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