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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Ferreira LT, Cassiano GC, Alvarez LCS, Okombo J, Calit J, Fontinha D, Gil-Iturbe E, Coyle R, Andrade CH, Sunnerhagen P, Bargieri DY, Prudêncio M, Quick M, Cravo PV, Lee MCS, Fidock DA, Costa FTM. Ferreira LT, et al. Among authors: fontinha d. PLoS Pathog. 2024 Oct 29;20(10):e1012627. doi: 10.1371/journal.ppat.1012627. eCollection 2024 Oct. PLoS Pathog. 2024. PMID: 39471233 Free PMC article.
Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Pavić K, Poje G, Pessanha de Carvalho L, Tandarić T, Marinović M, Fontinha D, Held J, Prudêncio M, Piantanida I, Vianello R, Krošl Knežević I, Perković I, Rajić Z. Pavić K, et al. Among authors: fontinha d. Bioorg Med Chem. 2024 May 1;105:117734. doi: 10.1016/j.bmc.2024.117734. Epub 2024 Apr 23. Bioorg Med Chem. 2024. PMID: 38677112
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads.
Fonte M, Fontinha D, Moita D, Caño-Prades O, Avalos-Padilla Y, Fernàndez-Busquets X, Prudêncio M, Gomes P, Teixeira C. Fonte M, et al. Among authors: fontinha d. Eur J Med Chem. 2023 Oct 5;258:115575. doi: 10.1016/j.ejmech.2023.115575. Epub 2023 Jun 22. Eur J Med Chem. 2023. PMID: 37390511 Free article.
Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro.
Breiterová KH, Ritomská A, Fontinha D, Křoustková J, Suchánková D, Hošťálková A, Šafratová M, Kohelová E, Peřinová R, Vrabec R, Francisco D, Prudêncio M, Cahlíková L. Breiterová KH, et al. Among authors: fontinha d. Pharmaceutics. 2023 Mar 21;15(3):1007. doi: 10.3390/pharmaceutics15031007. Pharmaceutics. 2023. PMID: 36986868 Free PMC article.
Corrigendum: Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine.
Silva AT, Oliveira IS, Gomes J, Aguiar L, Fontinha D, Duarte D, Nogueira F, Prudêncio M, Marques EF, Teixeira C, Ferraz R, Gomes P. Silva AT, et al. Among authors: fontinha d. ChemMedChem. 2023 Jan 3;18(1):e202200589. doi: 10.1002/cmdc.202200589. Epub 2022 Dec 8. ChemMedChem. 2023. PMID: 36480787 No abstract available.
52 results