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IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Andlovic B, Heilmann G, Ninck S, Andrei SA, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Andlovic B, et al. Among authors: eickhoff j. Cell Chem Biol. 2023 Jun 15;30(6):573-590.e6. doi: 10.1016/j.chembiol.2023.04.005. Epub 2023 May 1. Cell Chem Biol. 2023. PMID: 37130519 Free article.
Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction.
Andlovic B, Valenti D, Centorrino F, Picarazzi F, Hristeva S, Hiltmann M, Wolf A, Cantrelle FX, Mori M, Landrieu I, Levy LM, Klebl B, Tzalis D, Genski T, Eickhoff J, Ottmann C. Andlovic B, et al. Among authors: eickhoff j. Biochemistry. 2024 Sep 3;63(17):2196-2206. doi: 10.1021/acs.biochem.4c00248. Epub 2024 Aug 22. Biochemistry. 2024. PMID: 39172504 Free PMC article.
Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Among authors: eickhoff j. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Review.
Modulators of 14-3-3 Protein-Protein Interactions.
Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: eickhoff j. J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. J Med Chem. 2018. PMID: 28968506 Free PMC article. Review.
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
Aarhus TI, Bjørnstad F, Wolowczyk C, Larsen KU, Rognstad L, Leithaug T, Unger A, Habenberger P, Wolf A, Bjørkøy G, Pridans C, Eickhoff J, Klebl B, Hoff BH, Sundby E. Aarhus TI, et al. Among authors: eickhoff j. J Med Chem. 2023 May 25;66(10):6959-6980. doi: 10.1021/acs.jmedchem.3c00428. Epub 2023 May 16. J Med Chem. 2023. PMID: 37191268 Free PMC article.
Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate.
Sagurna L, Heinrich S, Kaufmann LS, Rückert-Reed C, Busche T, Wolf A, Eickhoff J, Klebl B, Kalinowski J, Bandow JE. Sagurna L, et al. Among authors: eickhoff j. Antibiotics (Basel). 2023 Jun 28;12(7):1116. doi: 10.3390/antibiotics12071116. Antibiotics (Basel). 2023. PMID: 37508212 Free PMC article.
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland.
Bjørnstad F, Havik S, Aarhus TI, Mahdi I, Unger A, Habenberger P, Degenhart C, Eickhoff J, Klebl BM, Sundby E, Hoff BH. Bjørnstad F, et al. Among authors: eickhoff j. Eur J Med Chem. 2024 Feb 5;265:116053. doi: 10.1016/j.ejmech.2023.116053. Epub 2023 Dec 17. Eur J Med Chem. 2024. PMID: 38141285 Free article.
A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.
Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M. Hutterer C, et al. Among authors: eickhoff j. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71. doi: 10.1128/AAC.04534-14. Epub 2015 Jan 26. Antimicrob Agents Chemother. 2015. PMID: 25624324 Free PMC article.
448 results