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Page 1
Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver.
MacKinnon AC, Humphries DC, Herman K, Roper JA, Holyer I, Mabbitt J, Mills R, Nilsson UJ, Leffler H, Pedersen A, Schambye H, Zetterberg F, Slack RJ. MacKinnon AC, et al. Among authors: slack rj. Eur J Pharmacol. 2024 Nov 9:177077. doi: 10.1016/j.ejphar.2024.177077. Online ahead of print. Eur J Pharmacol. 2024. PMID: 39528104
Single‑Dose Pharmacokinetics and Safety of the Oral Galectin‑3 Inhibitor, Selvigaltin (GB1211), in Participants with Hepatic Impairment.
Aslanis V, Gray M, Slack RJ, Zetterberg FR, Tonev D, Phung D, Smith B, Jacoby B, Schambye H, Krastev Z, Ungell AL, Lindmark B. Aslanis V, et al. Among authors: slack rj. Clin Drug Investig. 2024 Oct;44(10):773-787. doi: 10.1007/s40261-024-01395-7. Epub 2024 Oct 2. Clin Drug Investig. 2024. PMID: 39358661 Clinical Trial.
Relative bioavailability and food effect of the galectin-3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA-1).
Aslanis V, Abd-Elaziz K, Slack RJ, Brinch A, Gravelle L, Morley W, Phung D, Herman K, Holyer I, Poulsen KK, Dogterom P, Tantawi S, Zetterberg FR, Jacoby B, Schambye H, Lindmark B. Aslanis V, et al. Among authors: slack rj. Cancer Chemother Pharmacol. 2024 Nov;94(5):707-720. doi: 10.1007/s00280-024-04710-3. Epub 2024 Aug 21. Cancer Chemother Pharmacol. 2024. PMID: 39167148 Clinical Trial.
The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis.
Comeglio P, Guarnieri G, Filippi S, Cellai I, Acciai G, Holyer I, Zetterberg F, Leffler H, Kahl-Knutson B, Sarchielli E, Morelli A, Maggi M, Slack RJ, Vignozzi L. Comeglio P, et al. Among authors: slack rj. Front Pharmacol. 2024 Jul 31;15:1430109. doi: 10.3389/fphar.2024.1430109. eCollection 2024. Front Pharmacol. 2024. PMID: 39144627 Free PMC article.
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.
Zetterberg FR, Peterson K, Nilsson UJ, Andréasson Dahlgren K, Diehl C, Holyer I, Håkansson M, Khabut A, Kahl-Knutson B, Leffler H, MacKinnon AC, Roper JA, Slack RJ, Zarrizi R, Pedersen A. Zetterberg FR, et al. Among authors: slack rj. J Med Chem. 2024 Jun 13;67(11):9374-9388. doi: 10.1021/acs.jmedchem.4c00485. Epub 2024 May 28. J Med Chem. 2024. PMID: 38804039
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
Calver JF, Parmar NR, Harris G, Lithgo RM, Stylianou P, Zetterberg FR, Gooptu B, Mackinnon AC, Carr SB, Borthwick LA, Scott DJ, Stewart ID, Slack RJ, Jenkins RG, John AE. Calver JF, et al. Among authors: slack rj. J Biol Chem. 2024 Jun;300(6):107300. doi: 10.1016/j.jbc.2024.107300. Epub 2024 Apr 18. J Biol Chem. 2024. PMID: 38641066 Free PMC article.
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