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Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy.
Pandya P, Vendetti FP, El-Ghoubaira J, Pathak S, Deppas JJ, Jones R, Columbus AV, Zhang Y, Ivanov D, Huang Z, MacDonald KM, Harding SM, Buj R, Aird KM, Beumer JH, Sobol RW, Bakkenist CJ. Pandya P, et al. Among authors: bakkenist cj. bioRxiv [Preprint]. 2024 Apr 5:2024.04.04.588079. doi: 10.1101/2024.04.04.588079. bioRxiv. 2024. PMID: 38883769 Free PMC article. Preprint.
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice.
Deppas JJ, Kiesel BF, Guo J, Parise RA, Clump DA, D'Argenio DZ, Bakkenist CJ, Beumer JH. Deppas JJ, et al. Among authors: bakkenist cj. Cancer Chemother Pharmacol. 2024 Aug;94(2):271-283. doi: 10.1007/s00280-024-04675-3. Epub 2024 May 14. Cancer Chemother Pharmacol. 2024. PMID: 38743253 Free PMC article.
Metronomic dosing of ovarian cancer cells with the ATR inhibitor AZD6738 leads to loss of CDC25A expression and resistance to ATRi treatment.
Ao W, Kim HI, Tommarello D, Conrads KA, Hood BL, Litzi T, Abulez T, Teng PN, Dalgard CL, Zhang X, Wilkerson MD, Darcy KM, Tarney CM, Phippen NT, Bakkenist CJ, Maxwell GL, Conrads TP, Risinger JI, Bateman NW. Ao W, et al. Among authors: bakkenist cj. Gynecol Oncol. 2023 Oct;177:60-71. doi: 10.1016/j.ygyno.2023.08.004. Epub 2023 Aug 26. Gynecol Oncol. 2023. PMID: 37639904
Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice.
Sun R, Guo S, Shuda Y, Chakka AB, Rigatti LH, Zhao G, Ali MAE, Park CY, Chandran U, Yu J, Bakkenist CJ, Shuda M, Moore PS, Chang Y. Sun R, et al. Among authors: bakkenist cj. PLoS One. 2023 May 5;18(5):e0282722. doi: 10.1371/journal.pone.0282722. eCollection 2023. PLoS One. 2023. PMID: 37145994 Free PMC article.
Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression.
Sugitani N, Vendetti FP, Cipriano AJ, Pandya P, Deppas JJ, Moiseeva TN, Schamus-Haynes S, Wang Y, Palmer D, Osmanbeyoglu HU, Bostwick A, Snyder NW, Gong YN, Aird KM, Delgoffe GM, Beumer JH, Bakkenist CJ. Sugitani N, et al. Among authors: bakkenist cj. Cell Rep. 2022 Sep 20;40(12):111371. doi: 10.1016/j.celrep.2022.111371. Cell Rep. 2022. PMID: 36130512 Free PMC article.
80 results