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Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model.
Yang J, Riemann SB, Lyu J, Feng S, Bi Y, Lentini NA, Kang I, Kashemirov BA, Hartline CB, James SH, Tollefson AE, Cline-Smith A, Toth K, McKenna CE. Yang J, et al. Among authors: hartline cb. bioRxiv [Preprint]. 2024 Nov 1:2024.11.01.621456. doi: 10.1101/2024.11.01.621456. bioRxiv. 2024. PMID: 39554161 Free PMC article. Preprint.
Design and experimental validation of the oxazole and thiazole derivatives as potential antivirals against of human cytomegalovirus.
Kovalishyn V, Severin O, Kachaeva M, Semenyuta I, Keith KA, Harden EA, Hartline CB, James SH, Metelytsia L, Brovarets V. Kovalishyn V, et al. Among authors: hartline cb. SAR QSAR Environ Res. 2023 Jul-Sep;34(7):523-541. doi: 10.1080/1062936X.2023.2232992. Epub 2023 Jul 10. SAR QSAR Environ Res. 2023. PMID: 37424376 Free PMC article.
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: hartline cb. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.
Toth K, Spencer JF, Ying B, Tollefson AE, Hartline CB, Richard ET, Fan J, Lyu J, Kashemirov BA, Harteg C, Reyna D, Lipka E, Prichard MN, McKenna CE, Wold WSM. Toth K, et al. Among authors: hartline cb. Antiviral Res. 2018 May;153:1-9. doi: 10.1016/j.antiviral.2018.03.001. Epub 2018 Mar 3. Antiviral Res. 2018. PMID: 29510156 Free PMC article.
42 results