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Mapping of the p53 and mdm-2 interaction domains.
Chen J, Marechal V, Levine AJ. Chen J, et al. Mol Cell Biol. 1993 Jul;13(7):4107-14. doi: 10.1128/mcb.13.7.4107-4114.1993. Mol Cell Biol. 1993. PMID: 7686617 Free PMC article.
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein.
Chen J, Wu X, Lin J, Levine AJ. Chen J, et al. Mol Cell Biol. 1996 May;16(5):2445-52. doi: 10.1128/MCB.16.5.2445. Mol Cell Biol. 1996. PMID: 8628312 Free PMC article.
This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. J. Levine, Mol. Med. 1:142-152, 1995, and J. Momand, G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine, Cell 69:12 …
This physical interaction results in the inhibition of the transcriptional functions of p53 (J. Chen, J. Lin, and A. …
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