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Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor.
Saltz L, Sirott M, Young C, Tong W, Niedzwiecki D, Tzy-Jyun Y, Tao Y, Trochanowski B, Wright P, Barbosa K, et al. Saltz L, et al. Among authors: sirott m. J Natl Cancer Inst. 1993 Sep 15;85(18):1499-507. doi: 10.1093/jnci/85.18.1499. J Natl Cancer Inst. 1993. PMID: 7689654 Clinical Trial.