Rovnyak GC - Search Results

1

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.

Rovnyak GC, Kimball SD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang R, et al. Rovnyak GC, et al. J Med Chem. 1995 Jan 6;38(1):119-29. doi: 10.1021/jm00001a017. J Med Chem. 1995. PMID: 7837222

2

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF. Rovnyak GC, et al. J Med Chem. 1992 Aug 21;35(17):3254-63. doi: 10.1021/jm00095a023. J Med Chem. 1992. PMID: 1387168

3

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, Floyd DM. Atwal KS, et al. Among authors: rovnyak gc. J Med Chem. 1990 May;33(5):1510-5. doi: 10.1021/jm00167a035. J Med Chem. 1990. PMID: 2329573

4

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, Malley MF. Atwal KS, et al. Among authors: rovnyak gc. J Med Chem. 1990 Sep;33(9):2629-35. doi: 10.1021/jm00171a044. J Med Chem. 1990. PMID: 2391701

5

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site.

Kimball SD, Floyd DM, Das J, Hunt JT, Krapcho J, Rovnyak G, Duff KJ, Lee VG, Moquin RV, Turk CF, et al. Kimball SD, et al. J Med Chem. 1992 Feb 21;35(4):780-93. doi: 10.1021/jm00082a020. J Med Chem. 1992. PMID: 1311765

6

Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1991 Aug;34(8):2521-4. doi: 10.1021/jm00112a030. J Med Chem. 1991. PMID: 1652021

7

Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.

Rovnyak G, Andersen N, Gougoutas J, Hedberg A, Kimball SD, Malley M, Moreland S, Porubcan M, Pudzianowski A. Rovnyak G, et al. J Med Chem. 1988 May;31(5):936-44. doi: 10.1021/jm00400a008. J Med Chem. 1988. PMID: 2834556

8

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

Lloyd J, Schmidt JB, Rovnyak G, Ahmad S, Atwal KS, Bisaha SN, Doweyko LM, Stein PD, Traeger SC, Mathur A, Conder ML, DiMarco J, Harper TW, Jenkins-West T, Levesque PC, Normandin DE, Russell AD, Serafino RP, Smith MA, Lodge NJ. Lloyd J, et al. J Med Chem. 2001 Nov 8;44(23):3764-7. doi: 10.1021/jm015505u. J Med Chem. 2001. PMID: 11689063

9

Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.

Krapcho J, Turk C, Cushman DW, Powell JR, DeForrest JM, Spitzmiller ER, Karanewsky DS, Duggan M, Rovnyak G, Schwartz J, et al. Krapcho J, et al. J Med Chem. 1988 Jun;31(6):1148-60. doi: 10.1021/jm00401a014. J Med Chem. 1988. PMID: 2836590

10

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, Traeger SC. Rovnyak GC, et al. J Med Chem. 1997 Jan 3;40(1):24-34. doi: 10.1021/jm9605905. J Med Chem. 1997. PMID: 9016325

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