The EBNA-2 arginine-glycine domain is critical but not essential for B-lymphocyte growth transformation; the rest of region 3 lacks essential interactive domains.
Tong X, Yalamanchili R, Harada S, Kieff E.
Tong X, et al. Among authors: kieff e.
J Virol. 1994 Oct;68(10):6188-97. doi: 10.1128/JVI.68.10.6188-6197.1994.
J Virol. 1994.
PMID: 8083959
Free PMC article.
Since deletion of region 3 (amino acids [aa] 333 to 425) of Epstein-Barr virus nuclear protein 2 (EBNA-2) results in EBV recombinants which cannot transform primary B lymphocytes (J. I. Cohen, F. Wang, and E. Kieff, J. Virol. 65:2545-2554, 1991), the role of domains …
Since deletion of region 3 (amino acids [aa] 333 to 425) of Epstein-Barr virus nuclear protein 2 (EBNA-2) results in EBV recombinants which …