Tasker AS - Search Results

1

Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung.

Shiosaki K, Tasker AS, Sullivan GM, Sorensen BK, von Geldern TW, Wu-Wong JR, Marselle CA, Opgenorth TJ. Shiosaki K, et al. Among authors: tasker as. J Med Chem. 1993 Feb 19;36(4):468-78. doi: 10.1021/jm00056a007. J Med Chem. 1993. PMID: 8474103

2

Characterization of two endothelin converting enzymes and their preference for big endothelin-1 and -2 as substrates.

Chiou WJ, Shiosaki K, Tasker AS, Wu-Wong JR. Chiou WJ, et al. Among authors: tasker as. Life Sci. 1994;54(21):1613-9. doi: 10.1016/0024-3205(94)90033-7. Life Sci. 1994. PMID: 8196480

3

2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.

Winn M, von Geldern TW, Opgenorth TJ, Jae HS, Tasker AS, Boyd SA, Kester JA, Mantei RA, Bal R, Sorensen BK, Wu-Wong JR, Chiou WJ, Dixon DB, Novosad EI, Hernandez L, Marsh KC. Winn M, et al. Among authors: tasker as. J Med Chem. 1996 Mar 1;39(5):1039-48. doi: 10.1021/jm9505369. J Med Chem. 1996. PMID: 8676339

4

Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

Tasker AS, Sorensen BK, Jae HS, Winn M, von Geldern TW, Dixon DB, Chiou WJ, Dayton BD, Calzadila S, Hernandez L, Marsh KC, WuWong JR, Opgenorth TJ. Tasker AS, et al. J Med Chem. 1997 Jan 31;40(3):322-30. doi: 10.1021/jm960077r. J Med Chem. 1997. PMID: 9022798

5

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity.

Boyd SA, Mantei RA, Tasker AS, Liu G, Sorensen BK, Henry KJ Jr, von Geldern TW, Winn M, Wu-Wong JR, Chiou WJ, Dixon DB, Hutchins CW, Marsh KC, Nguyen B, Opgenorth TJ. Boyd SA, et al. Among authors: tasker as. Bioorg Med Chem. 1999 Jun;7(6):991-1002. doi: 10.1016/s0968-0896(99)00022-x. Bioorg Med Chem. 1999. PMID: 10428367

6

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.

von Geldern TW, Tasker AS, Sorensen BK, Winn M, Szczepankiewicz BG, Dixon DB, Chiou WJ, Wang L, Wessale JL, Adler A, Marsh KC, Nguyen B, Opgenorth TJ. von Geldern TW, et al. Among authors: tasker as. J Med Chem. 1999 Sep 9;42(18):3668-78. doi: 10.1021/jm990170q. J Med Chem. 1999. PMID: 10479298

7

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

Szczepankiewicz BG, Liu G, Jae HS, Tasker AS, Gunawardana IW, von Geldern TW, Gwaltney SL 2nd, Wu-Wong JR, Gehrke L, Chiou WJ, Credo RB, Alder JD, Nukkala MA, Zielinski NA, Jarvis K, Mollison KW, Frost DJ, Bauch JL, Hui YH, Claiborne AK, Li Q, Rosenberg SH. Szczepankiewicz BG, et al. Among authors: tasker as. J Med Chem. 2001 Dec 6;44(25):4416-30. doi: 10.1021/jm010231w. J Med Chem. 2001. PMID: 11728187

8

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.

Wu-Wong JR, Dixon DB, Chiou WJ, Sorensen BK, Liu G, Jae HS, Tasker A, von Geldern TW, Winn M, Opgenorth TJ. Wu-Wong JR, et al. Clin Sci (Lond). 2002 Aug;103 Suppl 48:107S-111S. doi: 10.1042/CS103S107S. Clin Sci (Lond). 2002. PMID: 12193066

9

Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy.

O'Connor SJ, Barr KJ, Wang L, Sorensen BK, Tasker AS, Sham H, Ng SC, Cohen J, Devine E, Cherian S, Saeed B, Zhang H, Lee JY, Warner R, Tahir S, Kovar P, Ewing P, Alder J, Mitten M, Leal J, Marsh K, Bauch J, Hoffman DJ, Sebti SM, Rosenberg SH. O'Connor SJ, et al. Among authors: tasker as. J Med Chem. 1999 Sep 9;42(18):3701-10. doi: 10.1021/jm9901935. J Med Chem. 1999. PMID: 10479301

10

[3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors.

Hancock AA, Surber BW, Rotert G, Thomas S, Tasker AS, Sorensen BK, Vodenlich AD, Opgenorth TJ, Kerkman DJ, DeBernardis JF. Hancock AA, et al. Among authors: tasker as. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. doi: 10.1016/0922-4106(94)90223-2. Eur J Pharmacol. 1994. PMID: 8206129

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