Siman R - Search Results

1

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.

Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS. Thinakaran G, et al. Among authors: siman r. J Biol Chem. 1996 Apr 19;271(16):9390-7. doi: 10.1074/jbc.271.16.9390. J Biol Chem. 1996. PMID: 8621605 Free article.

2

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.

Reaume AG, Howland DS, Trusko SP, Savage MJ, Lang DM, Greenberg BD, Siman R, Scott RW. Reaume AG, et al. Among authors: siman r. J Biol Chem. 1996 Sep 20;271(38):23380-8. doi: 10.1074/jbc.271.38.23380. J Biol Chem. 1996. PMID: 8798542 Free article.

3

Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Leveugle B, Ding W, Durkin JT, Mistretta S, Eisle J, Matic M, Siman R, Greenberg BD, Fillit HM. Leveugle B, et al. Among authors: siman r. Neurochem Int. 1997 Jun;30(6):543-8. doi: 10.1016/s0197-0186(96)00103-9. Neurochem Int. 1997. PMID: 9152995

4

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

Howland DS, Trusko SP, Savage MJ, Reaume AG, Lang DM, Hirsch JD, Maeda N, Siman R, Greenberg BD, Scott RW, Flood DG. Howland DS, et al. Among authors: siman r. J Biol Chem. 1998 Jun 26;273(26):16576-82. doi: 10.1074/jbc.273.26.16576. J Biol Chem. 1998. PMID: 9632729 Free article.

5

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.

Durkin JT, Murthy S, Husten EJ, Trusko SP, Savage MJ, Rotella DP, Greenberg BD, Siman R. Durkin JT, et al. Among authors: siman r. J Biol Chem. 1999 Jul 16;274(29):20499-504. doi: 10.1074/jbc.274.29.20499. J Biol Chem. 1999. PMID: 10400678 Free article.

6

Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.

Siman R, Flood DG, Thinakaran G, Neumar RW. Siman R, et al. J Biol Chem. 2001 Nov 30;276(48):44736-43. doi: 10.1074/jbc.M104092200. Epub 2001 Sep 26. J Biol Chem. 2001. PMID: 11574534 Free article.

7

Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain.

Howland DS, Savage MJ, Huntress FA, Wallace RE, Schwartz DA, Loh T, Melloni RH Jr, DeGennaro LJ, Greenberg BD, Siman R, et al. Howland DS, et al. Among authors: siman r. Neurobiol Aging. 1995 Jul-Aug;16(4):685-99. doi: 10.1016/0197-4580(95)00078-s. Neurobiol Aging. 1995. PMID: 8544921

8

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

Savage MJ, Trusko SP, Howland DS, Pinsker LR, Mistretta S, Reaume AG, Greenberg BD, Siman R, Scott RW. Savage MJ, et al. Among authors: siman r. J Neurosci. 1998 Mar 1;18(5):1743-52. doi: 10.1523/JNEUROSCI.18-05-01743.1998. J Neurosci. 1998. PMID: 9464999 Free PMC article.

9

Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.

Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Cummings BJ, et al. Among authors: siman r. Neurobiol Aging. 1996 Jul-Aug;17(4):653-9. doi: 10.1016/0197-4580(96)00062-0. Neurobiol Aging. 1996. PMID: 8832640

10

APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology.

Greenberg BD, Savage MJ, Howland DS, Ali SM, Siedlak SL, Perry G, Siman R, Scott RW. Greenberg BD, et al. Among authors: siman r. Neurobiol Aging. 1996 Mar-Apr;17(2):153-71. doi: 10.1016/0197-4580(96)00001-2. Neurobiol Aging. 1996. PMID: 8744397 Review. No abstract available.

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