CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
Cohen PS, Nakshatri H, Dennis J, Caragine T, Bianchi M, Cerami A, Tracey KJ.
Cohen PS, et al. Among authors: bianchi m.
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3967-71. doi: 10.1073/pnas.93.9.3967.
Proc Natl Acad Sci U S A. 1996.
PMID: 8632999
Free PMC article.
Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimm …
Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production a …