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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
Froelich CJ, Orth K, Turbov J, Seth P, Gottlieb R, Babior B, Shah GM, Bleackley RC, Dixit VM, Hanna W. Froelich CJ, et al. Among authors: shah gm. J Biol Chem. 1996 Nov 15;271(46):29073-9. doi: 10.1074/jbc.271.46.29073. J Biol Chem. 1996. PMID: 8910561 Free article.
160 results