Schofield PR - Search Results

1

Rajendra S, Lynch JW, Schofield PR. Rajendra S, et al. Among authors: schofield pr. Pharmacol Ther. 1997;73(2):121-46. doi: 10.1016/s0163-7258(96)00163-5. Pharmacol Ther. 1997. PMID: 9131721 Review.

2

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.

Vandenberg RJ, French CR, Barry PH, Shine J, Schofield PR. Vandenberg RJ, et al. Among authors: schofield pr. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1765-9. doi: 10.1073/pnas.89.5.1765. Proc Natl Acad Sci U S A. 1992. PMID: 1311851 Free PMC article.

3

Distinct agonist- and antagonist-binding sites on the glycine receptor.

Vandenberg RJ, Handford CA, Schofield PR. Vandenberg RJ, et al. Among authors: schofield pr. Neuron. 1992 Sep;9(3):491-6. doi: 10.1016/0896-6273(92)90186-h. Neuron. 1992. PMID: 1326295

4

Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor.

Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR. Rajendra S, et al. Among authors: schofield pr. J Biol Chem. 1994 Jul 22;269(29):18739-42. J Biol Chem. 1994. PMID: 7518444 Free article.

5

Molecular mechanisms of inherited startle syndromes.

Rajendra S, Schofield PR. Rajendra S, et al. Among authors: schofield pr. Trends Neurosci. 1995 Feb;18(2):80-2. Trends Neurosci. 1995. PMID: 7537418 Review.

6

The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.

Rajendra S, Vandenberg RJ, Pierce KD, Cunningham AM, French PW, Barry PH, Schofield PR. Rajendra S, et al. Among authors: schofield pr. EMBO J. 1995 Jul 3;14(13):2987-98. doi: 10.1002/j.1460-2075.1995.tb07301.x. EMBO J. 1995. PMID: 7621814 Free PMC article.

7

Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.

Lynch JW, Rajendra S, Barry PH, Schofield PR. Lynch JW, et al. Among authors: schofield pr. J Biol Chem. 1995 Jun 9;270(23):13799-806. doi: 10.1074/jbc.270.23.13799. J Biol Chem. 1995. PMID: 7775436 Free article.

8

Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists.

Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR. Rajendra S, et al. Among authors: schofield pr. Neuron. 1995 Jan;14(1):169-75. doi: 10.1016/0896-6273(95)90251-1. Neuron. 1995. PMID: 7826634 Free article.

9

The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site.

Vandenberg RJ, Rajendra S, French CR, Barry PH, Schofield PR. Vandenberg RJ, et al. Among authors: schofield pr. Mol Pharmacol. 1993 Jul;44(1):198-203. Mol Pharmacol. 1993. PMID: 8393521

10

The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.

Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR. Handford CA, et al. Among authors: schofield pr. Brain Res Mol Brain Res. 1996 Jan;35(1-2):211-9. Brain Res Mol Brain Res. 1996. PMID: 8717357

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