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Page 1
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
Rosen H, Hajdu R, Silver L, Kropp H, Dorso K, Kohler J, Sundelof JG, Huber J, Hammond GG, Jackson JJ, Gill CJ, Thompson R, Pelak BA, Epstein-Toney JH, Lankas G, Wilkening RR, Wildonger KJ, Blizzard TA, DiNinno FP, Ratcliffe RW, Heck JV, Kozarich JW, Hammond ML. Rosen H, et al. Among authors: silver l. Science. 1999 Jan 29;283(5402):703-6. doi: 10.1126/science.283.5402.703. Science. 1999. PMID: 9924033
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum beta-lactamase-and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates.
Kohler J, Dorso KL, Young K, Hammond GG, Rosen H, Kropp H, Silver LL. Kohler J, et al. Among authors: silver ll. Antimicrob Agents Chemother. 1999 May;43(5):1170-6. doi: 10.1128/AAC.43.5.1170. Antimicrob Agents Chemother. 1999. PMID: 10223931 Free PMC article.
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Among authors: silver ll. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421
Antibacterial agents that inhibit lipid A biosynthesis.
Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM, Chen MH, Patchett AA, Galloway SM, Hyland SA, Anderson MS, Raetz CR. Onishi HR, et al. Among authors: silver ll. Science. 1996 Nov 8;274(5289):980-2. doi: 10.1126/science.274.5289.980. Science. 1996. PMID: 8875939
582 results