Brehm L - Search Results

1

Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.

Johansen TN, Ebert B, Bräuner-Osborne H, Didriksen M, Christensen IT, Søby KK, Madsen U, Krogsgaard-Larsen P, Brehm L. Johansen TN, et al. Among authors: brehm l. J Med Chem. 1998 Mar 12;41(6):930-9. doi: 10.1021/jm9706731. J Med Chem. 1998. PMID: 9526567

2

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P. Brehm L, et al. J Med Chem. 2003 Apr 10;46(8):1350-8. doi: 10.1021/jm0204441. J Med Chem. 2003. PMID: 12672235

3

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS. Clausen RP, et al. Among authors: brehm l. J Med Chem. 2009 Aug 13;52(15):4911-22. doi: 10.1021/jm900565c. J Med Chem. 2009. PMID: 19588945

4

Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid.

Christensen IT, Ebert B, Madsen U, Nielsen B, Brehm L, Krogsgaard-Larsen P. Christensen IT, et al. Among authors: brehm l. J Med Chem. 1992 Sep 18;35(19):3512-9. doi: 10.1021/jm00097a008. J Med Chem. 1992. PMID: 1383544

5

Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.

Madsen U, Brehm L, Schaumburg K, Jørgensen FS, Krogsgaard-Larsen P. Madsen U, et al. Among authors: brehm l. J Med Chem. 1990 Jan;33(1):374-80. doi: 10.1021/jm00163a060. J Med Chem. 1990. PMID: 1967316

6

GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.

Nielsen L, Brehm L, Krogsgaard-Larsen P. Nielsen L, et al. Among authors: brehm l. J Med Chem. 1990 Jan;33(1):71-7. doi: 10.1021/jm00163a012. J Med Chem. 1990. PMID: 2153214

7

Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.

Hansen JJ, Nielsen B, Krogsgaard-Larsen P, Brehm L, Nielsen EO, Curtis DR. Hansen JJ, et al. Among authors: brehm l. J Med Chem. 1989 Oct;32(10):2254-60. doi: 10.1021/jm00130a005. J Med Chem. 1989. PMID: 2552114

8

Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].

Ebert B, Lenz S, Brehm L, Bregnedal P, Hansen JJ, Frederiksen K, Bøgesø KP, Krogsgaard-Larsen P. Ebert B, et al. Among authors: brehm l. J Med Chem. 1994 Apr 1;37(7):878-84. doi: 10.1021/jm00033a003. J Med Chem. 1994. PMID: 7512140

9

Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.

Frølund B, Kristiansen U, Brehm L, Hansen AB, Krogsgaard-Larsen P, Falch E. Frølund B, et al. Among authors: brehm l. J Med Chem. 1995 Aug 18;38(17):3287-96. doi: 10.1021/jm00017a014. J Med Chem. 1995. PMID: 7650683

10

N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

Madsen U, Frydenvang K, Ebert B, Johansen TN, Brehm L, Krogsgaard-Larsen P. Madsen U, et al. Among authors: brehm l. J Med Chem. 1996 Jan 5;39(1):183-90. doi: 10.1021/jm950393q. J Med Chem. 1996. PMID: 8568805

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