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Page 1
Presenilin 1 is actively degraded by the 26S proteasome.
Fraser PE, Levesque G, Yu G, Mills LR, Thirlwell J, Frantseva M, Gandy SE, Seeger M, Carlen PL, St George-Hyslop P. Fraser PE, et al. Among authors: seeger m. Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S19-21. doi: 10.1016/s0197-4580(98)00029-3. Neurobiol Aging. 1998. PMID: 9562462 Free article.
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Thinakaran G, et al. Among authors: seeger m. Neuron. 1996 Jul;17(1):181-90. doi: 10.1016/s0896-6273(00)80291-3. Neuron. 1996. PMID: 8755489 Free article.
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Lee MK, et al. Among authors: seeger m. J Neurosci. 1996 Dec 1;16(23):7513-25. doi: 10.1523/JNEUROSCI.16-23-07513.1996. J Neurosci. 1996. PMID: 8922407 Free PMC article.
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. Borchelt DR, et al. Among authors: seeger m. Neuron. 1996 Nov;17(5):1005-13. doi: 10.1016/s0896-6273(00)80230-5. Neuron. 1996. PMID: 8938131 Free article.
Protein topology of presenilin 1.
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Doan A, et al. Among authors: seeger m. Neuron. 1996 Nov;17(5):1023-30. doi: 10.1016/s0896-6273(00)80232-9. Neuron. 1996. PMID: 8938133 Free article.
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Seeger M, et al. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5090-4. doi: 10.1073/pnas.94.10.5090. Proc Natl Acad Sci U S A. 1997. PMID: 9144195 Free PMC article.
345 results