Hirschmann R - Search Results

1

Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase.

Smith AB 3rd, Sasho S, Barwis BA, Sprengeler P, Barbosa J, Hirschmann R, Cooperman BS. Smith AB 3rd, et al. Among authors: hirschmann r. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3133-6. doi: 10.1016/s0960-894x(98)00575-7. Bioorg Med Chem Lett. 1998. PMID: 9873690 Free article.

2

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: hirschmann r. J Med Chem. 2003 May 8;46(10):1831-44. doi: 10.1021/jm0204587. J Med Chem. 2003. PMID: 12723947

3

Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.

Smith AB 3rd, Nittoli T, Sprengeler PA, Duan JJ, Liu RQ, Hirschmann RF. Smith AB 3rd, et al. Among authors: hirschmann rf. Org Lett. 2000 Nov 30;2(24):3809-12. doi: 10.1021/ol000254p. Org Lett. 2000. PMID: 11101425

4

Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.

Hirschmann R, Yao W, Cascieri MA, Strader CD, Maechler L, Cichy-Knight MA, Hynes J Jr, van Rijn RD, Sprengeler PA, Smith AB 3rd. Hirschmann R, et al. J Med Chem. 1996 Jun 21;39(13):2441-8. doi: 10.1021/jm960281e. J Med Chem. 1996. PMID: 8691440

5

The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.

Smith AB 3rd, Knight SD, Sprengeler PA, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Bioorg Med Chem. 1996 Jul;4(7):1021-34. doi: 10.1016/0968-0896(96)00094-6. Bioorg Med Chem. 1996. PMID: 8831973 Free article.

6

Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.

Hirschmann R, Hynes J Jr, Cichy-Knight MA, van Rijn RD, Sprengeler PA, Spoors PG, Shakespeare WC, Pietranico-Cole S, Barbosa J, Liu J, Yao W, Rohrer S, Smith AB 3rd. Hirschmann R, et al. J Med Chem. 1998 Apr 23;41(9):1382-91. doi: 10.1021/jm9800346. J Med Chem. 1998. PMID: 9554871

7

Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold.

Smith AB 3rd, Favor DA, Sprengeler PA, Guzman MC, Carroll PJ, Furst GT, Hirschmann R. Smith AB 3rd, et al. Among authors: hirschmann r. Bioorg Med Chem. 1999 Jan;7(1):9-22. doi: 10.1016/s0968-0896(98)00234-x. Bioorg Med Chem. 1999. PMID: 10199652 Free article.

8

The carboxyl terminus heptapeptide of the R2 subunit of mammalian ribonucleotide reductase inhibits enzyme activity and can be used to purify the R1 subunit.

Yang FD, Spanevello RA, Celiker I, Hirschmann R, Rubin H, Cooperman BS. Yang FD, et al. Among authors: hirschmann r. FEBS Lett. 1990 Oct 15;272(1-2):61-4. doi: 10.1016/0014-5793(90)80449-s. FEBS Lett. 1990. PMID: 2226836 Free article.

9

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.

Smith AB 3rd, Hirschmann R, Pasternak A, Akaishi R, Guzman MC, Jones DR, Keenan TP, Sprengeler PA, Darke PL, Emini EA, et al. Smith AB 3rd, et al. Among authors: hirschmann r. J Med Chem. 1994 Jan 21;37(2):215-8. doi: 10.1021/jm00028a001. J Med Chem. 1994. PMID: 8295206 No abstract available.

10

Investigation of an antibody-ligase. Evidence for strain-induced catalysis.

Savinov SN, Hirschmann R, Benkovic SJ, Smith AB 3rd. Savinov SN, et al. Among authors: hirschmann r. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1321-4. doi: 10.1016/s0960-894x(03)00123-9. Bioorg Med Chem Lett. 2003. PMID: 12657273

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