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Replication stress and cancer: it takes two to tango.
Lecona E, Fernández-Capetillo O. Lecona E, et al. Exp Cell Res. 2014 Nov 15;329(1):26-34. doi: 10.1016/j.yexcr.2014.09.019. Epub 2014 Sep 26. Exp Cell Res. 2014. PMID: 25257608 Free PMC article. Review.
Modeling the study of DNA damage responses in mice.
Specks J, Nieto-Soler M, Lopez-Contreras AJ, Fernandez-Capetillo O. Specks J, et al. Methods Mol Biol. 2015;1267:413-37. doi: 10.1007/978-1-4939-2297-0_21. Methods Mol Biol. 2015. PMID: 25636482 Free PMC article. Review.
USP7 is a SUMO deubiquitinase essential for DNA replication.
Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. Lecona E, et al. Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950370 Free PMC article.
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KVM, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G. Winter GE, et al. Nat Chem Biol. 2014 Sep;10(9):768-773. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27. Nat Chem Biol. 2014. PMID: 25064833 Free PMC article.
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.
Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM. Saiz-Ladera C, et al. Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14. Oncogene. 2014. PMID: 24121270 Free PMC article.
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J. Farrés J, et al. Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12. Cell Death Differ. 2015. PMID: 25501596 Free PMC article.
A proteomic characterization of factors enriched at nascent DNA molecules.
Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodriguez-Acebes S, Remeseiro S, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O. Lopez-Contreras AJ, et al. Cell Rep. 2013 Apr 25;3(4):1105-16. doi: 10.1016/j.celrep.2013.03.009. Epub 2013 Mar 28. Cell Rep. 2013. PMID: 23545495 Free PMC article.
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