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Page 1
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. Herranz N, et al. Nat Cell Biol. 2015 Sep;17(9):1205-17. doi: 10.1038/ncb3225. Epub 2015 Aug 17. Nat Cell Biol. 2015. PMID: 26280535 Free PMC article.
Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.
Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ. Hanley CJ, et al. J Natl Cancer Inst. 2018 Jan 1;110(1):109-20. doi: 10.1093/jnci/djx121. J Natl Cancer Inst. 2018. PMID: 28922779 Free PMC article.
Pan-cancer deconvolution of tumour composition using DNA methylation.
Chakravarthy A, Furness A, Joshi K, Ghorani E, Ford K, Ward MJ, King EV, Lechner M, Marafioti T, Quezada SA, Thomas GJ, Feber A, Fenton TR. Chakravarthy A, et al. Nat Commun. 2018 Aug 13;9(1):3220. doi: 10.1038/s41467-018-05570-1. Nat Commun. 2018. PMID: 30104673 Free PMC article.
Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.
Ward MJ, Thirdborough SM, Mellows T, Riley C, Harris S, Suchak K, Webb A, Hampton C, Patel NN, Randall CJ, Cox HJ, Jogai S, Primrose J, Piper K, Ottensmeier CH, King EV, Thomas GJ. Ward MJ, et al. Br J Cancer. 2014 Jan 21;110(2):489-500. doi: 10.1038/bjc.2013.639. Epub 2013 Oct 29. Br J Cancer. 2014. PMID: 24169344 Free PMC article.
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.
Hanley CJ, Noble F, Ward M, Bullock M, Drifka C, Mellone M, Manousopoulou A, Johnston HE, Hayden A, Thirdborough S, Liu Y, Smith DM, Mellows T, Kao WJ, Garbis SD, Mirnezami A, Underwood TJ, Eliceiri KW, Thomas GJ. Hanley CJ, et al. Oncotarget. 2016 Feb 2;7(5):6159-74. doi: 10.18632/oncotarget.6740. Oncotarget. 2016. PMID: 26716418 Free PMC article.