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The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase.
Cancer Res. 2005 May 1;65(9):3883-93. doi: 10.1158/0008-5472.CAN-04-3757.
Cancer Res. 2005.
PMID: 15867388
Free PMC article.
Survivin deregulation in beta-tubulin mutant ovarian cancer cells underlies their compromised mitotic response to taxol.
Zhou J, O'brate A, Zelnak A, Giannakakou P.
Zhou J, et al.
Cancer Res. 2004 Dec 1;64(23):8708-14. doi: 10.1158/0008-5472.CAN-04-2538.
Cancer Res. 2004.
PMID: 15574781
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