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Re-routing GPR56 signalling using Gα12/13 G protein chimeras.
Faas F, Nørskov A, Holst PJ, Andersson AM, Qvortrup K, Mathiasen S, Rosenkilde MM. Faas F, et al. Basic Clin Pharmacol Toxicol. 2023 Oct;133(4):378-389. doi: 10.1111/bcpt.13935. Epub 2023 Sep 16. Basic Clin Pharmacol Toxicol. 2023. PMID: 37621135 Free article.
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.
Gasbjerg LS, Rasmussen RS, Dragan A, Lindquist P, Melchiorsen JU, Stepniewski TM, Schiellerup S, Tordrup EK, Gadgaard S, Kizilkaya HS, Willems S, Zhong Y, Wang Y, Wright SC, Lauschke VM, Hartmann B, Holst JJ, Selent J, Rosenkilde MM. Gasbjerg LS, et al. Br J Pharmacol. 2024 Jul 1. doi: 10.1111/bph.16478. Online ahead of print. Br J Pharmacol. 2024. PMID: 38952084