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Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release.
Harrington S, Knox JJ, Burns AR, Choo KL, Au A, Kitner M, Haeberli C, Pyche J, D'Amata C, Kim YH, Volpatti JR, Guiliani M, Snider J, Wong V, Palmeira BM, Redman EM, Vaidya AS, Gilleard JS, Stagljar I, Cutler SR, Kulke D, Dowling JJ, Yip CM, Keiser J, Zasada I, Lautens M, Roy PJ. Harrington S, et al. Commun Biol. 2022 Aug 24;5(1):865. doi: 10.1038/s42003-022-03819-6. Commun Biol. 2022. PMID: 36002479 Free PMC article.
Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.
Otten C, Knox J, Boulday G, Eymery M, Haniszewski M, Neuenschwander M, Radetzki S, Vogt I, Hähn K, De Luca C, Cardoso C, Hamad S, Igual Gil C, Roy P, Albiges-Rizo C, Faurobert E, von Kries JP, Campillos M, Tournier-Lasserve E, Derry WB, Abdelilah-Seyfried S. Otten C, et al. EMBO Mol Med. 2018 Oct;10(10):e9155. doi: 10.15252/emmm.201809155. EMBO Mol Med. 2018. PMID: 30181117 Free PMC article.
Caenorhabditis elegans is a useful model for anthelmintic discovery.
Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Burns AR, et al. Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485. Nat Commun. 2015. PMID: 26108372 Free PMC article.