Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development

Nat Immunol. 2024 Aug;25(8):1383-1394. doi: 10.1038/s41590-024-01882-1. Epub 2024 Jun 28.

Abstract

The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (TFH) cells are critical in helping B cells during germinal center reactions. In a T cell transfer colitis model, a lymphoid structure composed of mature dendritic cells (DCs) and TFH cells was found within T cell zones of colonic lymphoid follicles. TFH cells were required for mature DC accumulation, the formation of DC-T cell clusters and colitis development. Moreover, DCs promoted TFH cell differentiation, contributing to colitis development. A lineage-tracing analysis showed that, following migration to the lamina propria, TFH cells transdifferentiated into long-lived pathogenic TH1 cells, promoting colitis development. Our findings have therefore demonstrated the reciprocal regulation of TFH cells and DCs in colonic lymphoid follicles, which is critical in chronic colitis pathogenesis.

MeSH terms

  • Animals
  • Cell Differentiation* / immunology
  • Colitis* / immunology
  • Colitis* / pathology
  • Colon / immunology
  • Colon / pathology
  • Dendritic Cells* / immunology
  • Disease Models, Animal
  • Germinal Center / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • T Follicular Helper Cells* / immunology
  • Th1 Cells / immunology