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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C. Hutton C, et al. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34297917 Free PMC article.
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Graziano V, Dannhorn A, Hulme H, Williamson K, Buckley H, Karim SA, Wilson M, Lee SY, Kaistha BP, Islam S, Thaventhiran JED, Richards FM, Goodwin R, Brais R, Morton JP, Dovedi SJ, Schuller AG, Eyles J, Jodrell DI. Graziano V, et al. J Immunother Cancer. 2023 Aug;11(8):e006457. doi: 10.1136/jitc-2022-006457. J Immunother Cancer. 2023. PMID: 37553182 Free PMC article.
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer.
Brunton H, Caligiuri G, Cunningham R, Upstill-Goddard R, Bailey UM, Garner IM, Nourse C, Dreyer S, Jones M, Moran-Jones K, Wright DW, Paulus-Hock V, Nixon C, Thomson G, Jamieson NB, McGregor GA, Evers L, McKay CJ, Gulati A, Brough R, Bajrami I, Pettitt SJ, Dziubinski ML, Barry ST, Grützmann R, Brown R, Curry E; Glasgow Precision Oncology Laboratory; Australian Pancreatic Cancer Genome Initiative; Pajic M, Musgrove EA, Petersen GM, Shanks E, Ashworth A, Crawford HC, Simeone DM, Froeling FEM, Lord CJ, Mukhopadhyay D, Pilarsky C, Grimmond SE, Morton JP, Sansom OJ, Chang DK, Bailey PJ, Biankin AV. Brunton H, et al. Cell Rep. 2020 May 12;31(6):107625. doi: 10.1016/j.celrep.2020.107625. Cell Rep. 2020. PMID: 32402285 Free PMC article.
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