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Targeting the Choroid Plexuses for Protein Drug Delivery.
Bryniarski MA, Ren T, Rizvi AR, Snyder AM, Morris ME. Bryniarski MA, et al. Pharmaceutics. 2020 Oct 14;12(10):963. doi: 10.3390/pharmaceutics12100963. Pharmaceutics. 2020. PMID: 33066423 Free PMC article. Review.
Receptor-mediated transcytosis may be a promising mechanism to deliver protein therapeutics across the tight junctions formed by choroid plexus epithelial cells. ...This review aims to provide an overview of the choroid plexuses and ventricular system to address the …
Receptor-mediated transcytosis may be a promising mechanism to deliver protein therapeutics across the tight junctions formed …
Understanding Inter-Individual Variability in Monoclonal Antibody Disposition.
Thomas VA, Balthasar JP. Thomas VA, et al. Antibodies (Basel). 2019 Dec 4;8(4):56. doi: 10.3390/antib8040056. Antibodies (Basel). 2019. PMID: 31817205 Free PMC article. Review.
Monoclonal antibodies (mAbs) are currently the largest and most dominant class of therapeutic proteins. Inter-individual variability has been observed for several mAbs; however, an understanding of the underlying mechanisms and factors contributing to inter-subject …
Monoclonal antibodies (mAbs) are currently the largest and most dominant class of therapeutic proteins. Inter-individual varia …
Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE).
Chang HP, Cheung YK, Shah DK. Chang HP, et al. J Clin Med. 2021 Mar 23;10(6):1332. doi: 10.3390/jcm10061332. J Clin Med. 2021. PMID: 33807057 Free PMC article.
A physiological-based pharmacokinetic (PBPK) model was developed to characterize the whole-body PK of MMAE, which accounted for perfusion/permeability-limited transfer of drug in the tissue, blood cell distribution of the drug, tissue/tumor retention of the drug, and plasma pr …
A physiological-based pharmacokinetic (PBPK) model was developed to characterize the whole-body PK of MMAE, which accounted for perfusion/pe …
Half-Life Extension and Biodistribution Modulation of Biotherapeutics via Red Blood Cell Hitch-Hiking with Novel Anti-Band 3 Single-Domain Antibodies.
Nguyen TD, Bordeau BM, Zhang Y, Mattle AG, Balthasar JP. Nguyen TD, et al. Int J Mol Sci. 2022 Dec 28;24(1):475. doi: 10.3390/ijms24010475. Int J Mol Sci. 2022. PMID: 36613917 Free PMC article.
Small therapeutic proteins are receiving increased interest as therapeutic drugs; however, their clinical success has been limited due to their rapid elimination. ...This manuscript details the development and characterization of novel anti-RBC single-domain …
Small therapeutic proteins are receiving increased interest as therapeutic drugs; however, their clinical success has b …