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Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.
Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE. Onodera T, et al. Nat Commun. 2023 Oct 17;14(1):6531. doi: 10.1038/s41467-023-42188-4. Nat Commun. 2023. PMID: 37848446 Free PMC article.
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.
Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC. Deja S, et al. Cell Metab. 2024 May 7;36(5):1088-1104.e12. doi: 10.1016/j.cmet.2024.02.004. Epub 2024 Mar 5. Cell Metab. 2024. PMID: 38447582 Free article.
Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice.
Yiew NKH, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, Lutkewitte AJ, Mukherjee S, Fu X, Singer JM, Patti GJ, Burgess SC, Finck BN. Yiew NKH, et al. bioRxiv [Preprint]. 2023 Aug 24:2023.02.17.528992. doi: 10.1101/2023.02.17.528992. bioRxiv. 2023. Update in: iScience. 2023 Oct 12;26(11):108196. doi: 10.1016/j.isci.2023.108196. PMID: 36824879 Free PMC article. Updated. Preprint.