R01 AG070154/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	1
2021	1
2022	4
2023	5
2024	4

1

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration.

de Luzy IR, Lee MK, Mobley WC, Studer L. de Luzy IR, et al. Nat Aging. 2024 Mar;4(3):309-318. doi: 10.1038/s43587-024-00586-3. Epub 2024 Mar 1. Nat Aging. 2024. PMID: 38429379 Review.

2

Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain.

Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH. Wang M, et al. Nat Biotechnol. 2024 Feb 28:10.1038/s41587-024-02157-8. doi: 10.1038/s41587-024-02157-8. Online ahead of print. Nat Biotechnol. 2024. PMID: 38418648

3

Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain.

Fu XD, Mobley WC. Fu XD, et al. Annu Rev Neurosci. 2023 Jul 10;46:145-165. doi: 10.1146/annurev-neuro-083022-113120. Annu Rev Neurosci. 2023. PMID: 37428606 Free article. Review.

4

Editorial: Current advances in the study of Down Syndrome: From development to aging.

Johnstone A, Mobley W. Johnstone A, et al. Front Neurosci. 2023 Mar 20;17:1161147. doi: 10.3389/fnins.2023.1161147. eCollection 2023. Front Neurosci. 2023. PMID: 37021132 Free PMC article. No abstract available.

5

Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.

Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC. Chen XQ, et al. Ann Neurol. 2023 Aug;94(2):245-258. doi: 10.1002/ana.26659. Epub 2023 Apr 29. Ann Neurol. 2023. PMID: 37042072

6

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.

Bartesaghi R, Vicari S, Mobley WC. Bartesaghi R, et al. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:211-233. doi: 10.1146/annurev-pharmtox-041521-103641. Annu Rev Pharmacol Toxicol. 2022. PMID: 34990205 Free PMC article.

7

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Chen XQ, Zuo X, Becker A, Head E, Mobley WC. Chen XQ, et al. Alzheimers Dement. 2023 May;19(5):2095-2116. doi: 10.1002/alz.12835. Epub 2022 Nov 12. Alzheimers Dement. 2023. PMID: 36370135 Free PMC article.

8

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC. Chen XQ, et al. Ann Neurol. 2024 Aug;96(2):390-404. doi: 10.1002/ana.26958. Epub 2024 May 15. Ann Neurol. 2024. PMID: 38747498

9

Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.

Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. Sawa M, et al. Alzheimers Dement. 2022 Jun;18(6):1203-1234. doi: 10.1002/alz.12463. Epub 2021 Nov 10. Alzheimers Dement. 2022. PMID: 34757693 Free PMC article.

10

Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of p16^INK4a.

Zhu Y, Tazearslan C, Rosenfeld MG, Fiser A, Suh Y. Zhu Y, et al. Aging Cell. 2023 Sep;22(9):e13908. doi: 10.1111/acel.13908. Epub 2023 Jun 22. Aging Cell. 2023. PMID: 37345431 Free PMC article.

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