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Page 1
Toll-like Receptors and the Control of Immunity.
Fitzgerald KA, Kagan JC. Fitzgerald KA, et al. Cell. 2020 Mar 19;180(6):1044-1066. doi: 10.1016/j.cell.2020.02.041. Epub 2020 Mar 11. Cell. 2020. PMID: 32164908 Free PMC article. Review.
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H. Du G, et al. Nature. 2024 Jun;630(8016):437-446. doi: 10.1038/s41586-024-07373-5. Epub 2024 Apr 10. Nature. 2024. PMID: 38599239
Gasdermin D pore-forming activity is redox-sensitive.
Devant P, Boršić E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovič I, Evavold CL, Kagan JC. Devant P, et al. Cell Rep. 2023 Jan 31;42(1):112008. doi: 10.1016/j.celrep.2023.112008. Epub 2023 Jan 19. Cell Rep. 2023. PMID: 36662620 Free PMC article.
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.
Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR. Balasubramanian A, et al. Sci Immunol. 2024 Apr 12;9(94):eadn1452. doi: 10.1126/sciimmunol.adn1452. Epub 2024 Apr 12. Sci Immunol. 2024. PMID: 38530158
How Inflammasomes Inform Adaptive Immunity.
Evavold CL, Kagan JC. Evavold CL, et al. J Mol Biol. 2018 Jan 19;430(2):217-237. doi: 10.1016/j.jmb.2017.09.019. Epub 2017 Oct 5. J Mol Biol. 2018. PMID: 28987733 Free PMC article. Review.
49 results