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Reversing Post-Infectious Epigenetic-Mediated Immune Suppression.
Abhimanyu, Ontiveros CO, Guerra-Resendez RS, Nishiguchi T, Ladki M, Hilton IB, Schlesinger LS, DiNardo AR. Abhimanyu, et al. Front Immunol. 2021 Jun 7;12:688132. doi: 10.3389/fimmu.2021.688132. eCollection 2021. Front Immunol. 2021. PMID: 34163486 Free PMC article. Review.
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.
Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, Corcini Berndt M, Rojas J, Li H, Rinchai D, Erazo-Borrás L, Han JE, Pillay B, Ponsin K, Chaldebas M, Philippot Q, Bohlen J, Rosain J, Le Voyer T, Janotte T, Amarajeeva K, Soudée C, Brollo M, Wiegmann K, Marquant Q, Seeleuthner Y, Lee D, Lainé C, Kloos D, Bailey R, Bastard P, Keating N, Rapaport F, Khan T, Moncada-Vélez M, Carmona MC, Obando C, Alvarez J, Cataño JC, Martínez-Rosado LL, Sanchez JP, Tejada-Giraldo M, L'Honneur AS, Agudelo ML, Perez-Zapata LJ, Arboleda DM, Alzate JF, Cabarcas F, Zuluaga A, Pelham SJ, Ensser A, Schmidt M, Velásquez-Lopera MM, Jouanguy E, Puel A, Krönke M, Ghirardello S, Borghesi A, Pahari S, Boisson B, Pittaluga S, Ma CS, Emile JF, Notarangelo LD, Tangye SG, Marr N, Lachmann N, Salvator H, Schlesinger LS, Zhang P, Glickman MS, Nathan CF, Geissmann F, Abel L, Franco JL, Bustamante J, Casanova JL, Boisson-Dupuis S. Arias AA, et al. Nature. 2024 Sep;633(8029):417-425. doi: 10.1038/s41586-024-07866-3. Epub 2024 Aug 28. Nature. 2024. PMID: 39198650 Free PMC article.
Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling.
Leopold Wager CM, Bonifacio JR, Simper J, Naoun AA, Arnett E, Schlesinger LS. Leopold Wager CM, et al. PLoS Pathog. 2023 Mar 31;19(3):e1011297. doi: 10.1371/journal.ppat.1011297. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 37000865 Free PMC article.
E-cigs put the squeeze on macrophages.
Arnett E, Schlesinger LS. Arnett E, et al. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2418528121. doi: 10.1073/pnas.2418528121. Epub 2024 Oct 21. Proc Natl Acad Sci U S A. 2024. PMID: 39432798 No abstract available.
A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases.
Pahari S, Arnett E, Simper J, Azad A, Guerrero-Arguero I, Ye C, Zhang H, Cai H, Wang Y, Lai Z, Jarvis N, Lumbreras M, Maselli-Caceres DJ, Peters J, Torrelles JB, Martinez-Sobrido L, Schlesinger LS. Pahari S, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535806. doi: 10.1101/2023.04.05.535806. bioRxiv. 2023. Update in: mBio. 2023 Aug 31;14(4):e0083423. doi: 10.1128/mbio.00834-23. PMID: 37066199 Free PMC article. Updated. Preprint.