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Live, attenuated simian immunodeficiency virus SIVmac-M4, with point mutations in the Env transmembrane protein intracytoplasmic domain, provides partial protection from mucosal challenge with pathogenic SIVmac251.
Shacklett BL, Shaw KE, Adamson LA, Wilkens DT, Cox CA, Montefiori DC, Gardner MB, Sonigo P, Luciw PA. Shacklett BL, et al. J Virol. 2002 Nov;76(22):11365-78. doi: 10.1128/jvi.76.22.11365-11378.2002. J Virol. 2002. PMID: 12388697 Free PMC article.