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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. Kim J, et al. Nature. 2017 Jun 1;546(7656):168-172. doi: 10.1038/nature22359. Epub 2017 May 24. Nature. 2017. PMID: 28538732 Free PMC article.
Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.
Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH. Cuevas IC, et al. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25880-25890. doi: 10.1073/pnas.1911310116. Epub 2019 Nov 26. Proc Natl Acad Sci U S A. 2019. PMID: 31772025 Free PMC article.
Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies.
Sahoo SS, Aguilar M, Xu Y, Lucas E, Miller V, Chen H, Zheng W, Cuevas IC, Li HD, Hitrys D, Wachsmann MB, Bishop JA, Cantarell B, Gagan J, Koduru P, SoRelle JA, Castrillon DH. Sahoo SS, et al. Mod Pathol. 2022 Nov;35(11):1702-1712. doi: 10.1038/s41379-022-01124-5. Epub 2022 Jul 7. Mod Pathol. 2022. PMID: 35798968 Free PMC article.