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Page 1
Enhancer release and retargeting activates disease-susceptibility genes.
Oh S, Shao J, Mitra J, Xiong F, D'Antonio M, Wang R, Garcia-Bassets I, Ma Q, Zhu X, Lee JH, Nair SJ, Yang F, Ohgi K, Frazer KA, Zhang ZD, Li W, Rosenfeld MG. Oh S, et al. Nature. 2021 Jul;595(7869):735-740. doi: 10.1038/s41586-021-03577-1. Epub 2021 May 26. Nature. 2021. PMID: 34040254 Free PMC article.
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.
Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. Abe Y, et al. Mol Cell. 2023 Oct 5;83(19):3421-3437.e11. doi: 10.1016/j.molcel.2023.08.029. Epub 2023 Sep 25. Mol Cell. 2023. PMID: 37751740 Free PMC article.
A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation.
Abe Y, Kofman ER, Ouyang Z, Cruz-Becerra G, Spann NJ, Seidman JS, Troutman TD, Stender JD, Taylor H, Fan W, Link VM, Shen Z, Sakai J, Downes M, Evans RM, Kadonaga JT, Rosenfeld MG, Glass CK. Abe Y, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2316104121. doi: 10.1073/pnas.2316104121. Epub 2024 Jan 2. Proc Natl Acad Sci U S A. 2024. PMID: 38165941 Free PMC article.
43 results