Abstract
Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating mitochondrial activity.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetates / metabolism
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Animals
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Apoptosis
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Citric Acid Cycle
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Electron Transport
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Glycolysis
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Humans
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Insulin / metabolism
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Lipid Metabolism
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Liver / metabolism
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Mitochondria / metabolism*
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Muscle, Skeletal / metabolism
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Oxidative Stress
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Signal Transduction
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Sirtuins / metabolism*
Substances
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Acetates
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Insulin
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Sirtuins