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2018 211
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2020 146
2021 10
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504 results

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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N. Li B, et al. Nat Commun. 2020 Jan 9;11(1):164. doi: 10.1038/s41467-019-13965-x. Nat Commun. 2020. PMID: 31919360 Free PMC article.
We validate the host factors, WDR7, CCDC115 and TMEM199, demonstrating that these genes are essential for viral entry and regulation of V-type ATPase assembly. We also find that CMTR1, a human mRNA cap methyltransferase, is required for efficient viral cap snatching and re …
We validate the host factors, WDR7, CCDC115 and TMEM199, demonstrating that these genes are essential for viral entry and regulation of V-ty …
Sex matters.
Bale TL. Bale TL. Neuropsychopharmacology. 2019 Jan;44(1):1-3. doi: 10.1038/s41386-018-0239-x. Epub 2018 Oct 10. Neuropsychopharmacology. 2019. PMID: 30361539 Free PMC article. No abstract available.
Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor.
Chen H, Liu S, Padula S, Lesman D, Griswold K, Lin A, Zhao T, Marshall JL, Chen F. Chen H, et al. Nat Biotechnol. 2020 Feb;38(2):165-168. doi: 10.1038/s41587-019-0331-8. Epub 2019 Dec 16. Nat Biotechnol. 2020. PMID: 31844291 Free PMC article.
Here we describe TRACE (T7 polymerase-driven continuous editing), a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high rates of mutagenesis over multiple cell generations in genes un …
Here we describe TRACE (T7 polymerase-driven continuous editing), a method that enables continuous, targeted mutagenesis in human cel …
Effects of dietary components on intestinal permeability in health and disease.
Khoshbin K, Camilleri M. Khoshbin K, et al. Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1;319(5):G589-G608. doi: 10.1152/ajpgi.00245.2020. Epub 2020 Sep 9. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32902315 Free PMC article. Review.
Our aim was to examine the effects of diet components on the intestinal barrier in health and disease states. Herein, we conducted an in-depth PubMed search based on specific key words (diet, permeability, barrier, health, disease, and disorder), as well as cross re …
Our aim was to examine the effects of diet components on the intestinal barrier in health and disease states. Herein, we conducted an …
An immune-cell signature of bacterial sepsis.
Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. Reyes M, et al. Nat Med. 2020 Mar;26(3):333-340. doi: 10.1038/s41591-020-0752-4. Epub 2020 Feb 17. Nat Med. 2020. PMID: 32066974 Free PMC article.
We identified a panel of surface markers for isolation and quantification of the monocyte state and characterized its epigenomic and functional phenotypes, and propose a model for its induction from human bone marrow. This study demonstrates the utility of single-cell geno …
We identified a panel of surface markers for isolation and quantification of the monocyte state and characterized its epigenomic and functio …
Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors.
Wang C, Holtzman DM. Wang C, et al. Neuropsychopharmacology. 2020 Jan;45(1):104-120. doi: 10.1038/s41386-019-0478-5. Epub 2019 Aug 13. Neuropsychopharmacology. 2020. PMID: 31408876 Free PMC article. Review.
New findings from our group reveal that acute sleep deprivation increases levels of tau in mouse brain interstitial fluid (ISF) and human cerebrospinal fluid (CSF) and chronic sleep deprivation accelerates the spread of tau protein aggregates in neural networks. ...
New findings from our group reveal that acute sleep deprivation increases levels of tau in mouse brain interstitial fluid (ISF) and human …
A single-cell atlas of the peripheral immune response in patients with severe COVID-19.
Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martínez-Colón GJ, McKechnie JL, Ivison GT, Ranganath T, Vergara R, Hollis T, Simpson LJ, Grant P, Subramanian A, Rogers AJ, Blish CA. Wilk AJ, et al. Nat Med. 2020 Jul;26(7):1070-1076. doi: 10.1038/s41591-020-0944-y. Epub 2020 Jun 8. Nat Med. 2020. PMID: 32514174 Free PMC article.
Adaptation decorrelates shape representations.
Mattar MG, Olkkonen M, Epstein RA, Aguirre GK. Mattar MG, et al. Nat Commun. 2018 Sep 19;9(1):3812. doi: 10.1038/s41467-018-06278-y. Nat Commun. 2018. PMID: 30232324 Free PMC article.
Hydrophobic gating in BK channels.
Jia Z, Yazdani M, Zhang G, Cui J, Chen J. Jia Z, et al. Nat Commun. 2018 Aug 24;9(1):3408. doi: 10.1038/s41467-018-05970-3. Nat Commun. 2018. PMID: 30143620 Free PMC article.
504 results