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DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia.
Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. Lam LKM, et al. Sci Transl Med. 2021 Oct 20;13(616):eabj1008. doi: 10.1126/scitranslmed.abj1008. Epub 2021 Oct 20. Sci Transl Med. 2021. PMID: 34669439 Free PMC article.
Collateral damage: necroptosis in the development of lung injury.
Faust H, Mangalmurti NS. Faust H, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L215-L225. doi: 10.1152/ajplung.00065.2019. Epub 2019 Nov 27. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31774305 Free PMC article. Review.
Erythrocytes identify complement activation in patients with COVID-19.
Lam LKM, Reilly JP, Rux AH, Murphy SJ, Kuri-Cervantes L, Weisman AR, Ittner CAG, Pampena MB, Betts MR, Wherry EJ, Song WC, Lambris JD, Meyer NJ, Cines DB, Mangalmurti NS. Lam LKM, et al. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L485-L489. doi: 10.1152/ajplung.00231.2021. Epub 2021 Jul 7. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34231390 Free PMC article.