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IRGM1 links mitochondrial quality control to autoimmunity.
Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. Rai P, et al. Nat Immunol. 2021 Mar;22(3):312-321. doi: 10.1038/s41590-020-00859-0. Epub 2021 Jan 28. Nat Immunol. 2021. PMID: 33510463 Free PMC article.
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.
Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. Ngo J, et al. EMBO J. 2023 Jun 1;42(11):e111901. doi: 10.15252/embj.2022111901. Epub 2023 Mar 14. EMBO J. 2023. PMID: 36917141 Free PMC article.
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.
Acin-Perez R, Benincá C, Fernandez Del Rio L, Shu C, Baghdasarian S, Zanette V, Gerle C, Jiko C, Khairallah R, Khan S, Rincon Fernandez Pacheco D, Shabane B, Erion K, Masand R, Dugar S, Ghenoiu C, Schreiner G, Stiles L, Liesa M, Shirihai OS. Acin-Perez R, et al. EMBO J. 2023 May 15;42(10):e111699. doi: 10.15252/embj.2022111699. Epub 2023 Mar 13. EMBO J. 2023. PMID: 36912136 Free PMC article.
Recruitment and remodeling of peridroplet mitochondria in human adipose tissue.
Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. Acín-Perez R, et al. Redox Biol. 2021 Oct;46:102087. doi: 10.1016/j.redox.2021.102087. Epub 2021 Jul 30. Redox Biol. 2021. PMID: 34411987 Free PMC article.
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