R21 AI164088/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2021	1
2022	6
2023	2
2024	4

1

Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir.

Yang KS, Leeuwon SZ, Xu S, Liu WR. Yang KS, et al. J Med Chem. 2022 Jul 14;65(13):8686-8698. doi: 10.1021/acs.jmedchem.2c00404. Epub 2022 Jun 22. J Med Chem. 2022. PMID: 35731933 Free PMC article. Review.

2

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.

Alugubelli YR, Xiao J, Khatua K, Kumar S, Sun L, Ma Y, Ma XR, Vulupala VR, Atla S, Blankenship LR, Coleman D, Xie X, Neuman BW, Liu WR, Xu S. Alugubelli YR, et al. J Med Chem. 2024 Apr 25;67(8):6495-6507. doi: 10.1021/acs.jmedchem.3c02416. Epub 2024 Apr 12. J Med Chem. 2024. PMID: 38608245 Free PMC article.

3

A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.

Alugubelli YR, Geng ZZ, Yang KS, Shaabani N, Khatua K, Ma XR, Vatansever EC, Cho CC, Ma Y, Xiao J, Blankenship LR, Yu G, Sankaran B, Li P, Allen R, Ji H, Xu S, Liu WR. Alugubelli YR, et al. Eur J Med Chem. 2022 Oct 5;240:114596. doi: 10.1016/j.ejmech.2022.114596. Epub 2022 Jul 8. Eur J Med Chem. 2022. PMID: 35839690 Free PMC article.

4

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.

Geng ZZ, Atla S, Shaabani N, Vulupala V, Yang KS, Alugubelli YR, Khatua K, Chen PH, Xiao J, Blankenship LR, Ma XR, Vatansever EC, Cho CD, Ma Y, Allen R, Ji H, Xu S, Liu WR. Geng ZZ, et al. J Med Chem. 2023 Aug 24;66(16):11040-11055. doi: 10.1021/acs.jmedchem.3c00221. Epub 2023 Aug 10. J Med Chem. 2023. PMID: 37561993 Free PMC article.

5

A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.

Ma Y, Yang KS, Geng ZZ, Alugubelli YR, Shaabani N, Vatansever EC, Ma XR, Cho CC, Khatua K, Xiao J, Blankenship LR, Yu G, Sankaran B, Li P, Allen R, Ji H, Xu S, Liu WR. Ma Y, et al. Eur J Med Chem. 2022 Oct 5;240:114570. doi: 10.1016/j.ejmech.2022.114570. Epub 2022 Jun 27. Eur J Med Chem. 2022. PMID: 35779291 Free PMC article.

6

Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors.

Khatua K, Alugubelli YR, Yang KS, Vulupala VR, Blankenship LR, Coleman D, Atla S, Chaki SP, Geng ZZ, Ma XR, Xiao J, Chen PH, Cho CD, Sharma S, Vatansever EC, Ma Y, Yu G, Neuman BW, Xu S, Liu WR. Khatua K, et al. Antiviral Res. 2024 May;225:105874. doi: 10.1016/j.antiviral.2024.105874. Epub 2024 Mar 28. Antiviral Res. 2024. PMID: 38555023

7

Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay.

Cao W, Cho CD, Geng ZZ, Shaabani N, Ma XR, Vatansever EC, Alugubelli YR, Ma Y, Chaki SP, Ellenburg WH, Yang KS, Qiao Y, Allen R, Neuman BW, Ji H, Xu S, Liu WR. Cao W, et al. ACS Cent Sci. 2022 Feb 23;8(2):192-204. doi: 10.1021/acscentsci.1c00910. Epub 2022 Feb 2. ACS Cent Sci. 2022. PMID: 35229034 Free PMC article.

8

MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L.

Ma XR, Alugubelli YR, Ma Y, Vatansever EC, Scott DA, Qiao Y, Yu G, Xu S, Liu WR. Ma XR, et al. ChemMedChem. 2022 Jan 5;17(1):e202100456. doi: 10.1002/cmdc.202100456. Epub 2021 Jul 29. ChemMedChem. 2022. PMID: 34242492 Free PMC article.

9

BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease.

Sheng YJ, Kuo SA, Yang T, Zhang HE, Russell DH, Yan X, Xu S, Liu WR, Fierke CA. Sheng YJ, et al. Biochemistry. 2024 Feb 8:10.1021/acs.biochem.3c00685. doi: 10.1021/acs.biochem.3c00685. Online ahead of print. Biochemistry. 2024. PMID: 38329238

10

SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.

Blankenship LR, Yang KS, Vulupala VR, Alugubelli YR, Khatua K, Coleman D, Ma XR, Sankaran B, Cho CD, Ma Y, Neuman BW, Xu S, Liu WR. Blankenship LR, et al. ACS Med Chem Lett. 2024 May 20;15(6):950-957. doi: 10.1021/acsmedchemlett.4c00146. eCollection 2024 Jun 13. ACS Med Chem Lett. 2024. PMID: 38894905 Free PMC article.

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