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Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Genome Res. 2009 Sep;19(9):1507-15. doi: 10.1101/gr.090241.108. Epub 2009 May 5.
Genome Res. 2009.
PMID: 19416960
Free PMC article.
Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.
Fannin RD, Russo M, O'Connell TM, Gerrish K, Winnike JH, Macdonald J, Newton J, Malik S, Sieber SO, Parker J, Shah R, Zhou T, Watkins PB, Paules RS.
Fannin RD, et al.
Hepatology. 2010 Jan;51(1):227-36. doi: 10.1002/hep.23330.
Hepatology. 2010.
PMID: 19918972
Free PMC article.
Clinical Trial.
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Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.
Fannin RD, Gerrish K, Sieber SO, Bushel PR, Watkins PB, Paules RS.
Fannin RD, et al.
Clin Pharmacol Ther. 2016 Apr;99(4):432-41. doi: 10.1002/cpt.328. Epub 2016 Feb 22.
Clin Pharmacol Ther. 2016.
PMID: 26690555
Free PMC article.
Clinical Trial.
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