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Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES. Sorets AG, et al. bioRxiv [Preprint]. 2024 Sep 7:2024.06.09.598079. doi: 10.1101/2024.06.09.598079. bioRxiv. 2024. PMID: 38915549 Free PMC article. Preprint.