Establishing a high-risk neuroblastoma cohort using the Pediatric Health Information System Database

Pediatr Blood Cancer. 2014 Jun;61(6):1129-1131. doi: 10.1002/pbc.24930. Epub 2014 Jan 13.

Abstract

International Classification of Diseases, 9th Revision (ICD-9) code(s) for neuroblastoma do not exist, preventing identification of these patients in administrative databases. To overcome this challenge, a three-step algorithm, using ICD-9 codes, exclusion criteria, and manual review of chemotherapy billing data, was utilized to assemble a high-risk neuroblastoma cohort (n = 952) from the Pediatric Health Information System (PHIS) Database and validated at a single institution [sensitivity 89.1%; positive predictive value (PPV) 96.1%]. This cohort provides a data source for future comparative effectiveness and clinical epidemiology studies in high-risk neuroblastoma patients.

Keywords: administrative database; cohort validation; neuroblastoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Antineoplastic Agents / economics
  • Cancer Care Facilities / statistics & numerical data
  • Child
  • Child, Preschool
  • Cohort Studies
  • Databases, Factual*
  • Drug Utilization / economics
  • Female
  • Health Information Systems / statistics & numerical data*
  • Health Resources / statistics & numerical data
  • Hospitals, Pediatric / statistics & numerical data
  • Humans
  • Infant
  • Inpatients / statistics & numerical data
  • International Classification of Diseases
  • Male
  • Neuroblastoma / diagnosis
  • Neuroblastoma / drug therapy
  • Neuroblastoma / epidemiology*
  • Prescription Fees
  • Risk
  • Tertiary Care Centers / statistics & numerical data
  • United States / epidemiology
  • Young Adult

Substances

  • Antineoplastic Agents